• 1
    Li Y, Dai M, Chen Y, Zhang S, Chen W, Dai Z, Zou X. Estimates of lung cancer mortality at the province level in China. Zhongguo Fei Ai Za Zhi 2011; 14: 1206.
  • 2
    Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010; 60: 277300.
  • 3
    Zheng J, Liu B, Zhang L, Jiang L, Huang B, You Y, Jiang Q, Zhang S, Lu J, Zhou Y. The protective role of polymorphism MKK4 −1304 T>G in nasopharyngeal carcinoma is modulated by Epstein-Barr virus' infection status. Int J Cancer 2011. (PMID: 21702039).
  • 4
    Liu B, Chen D, Yang L, Li Y, Ling X, Liu L, Ji W, Wei Y, Wang J, Wei Q, Wang L, Lu J. A functional variant (−1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity. Carcinogenesis 2010; 31: 140511.
  • 5
    Feng Z, Ni Y, Dong W, Shen H, Du J. Association of ERCC2/XPD polymorphisms and interaction with tobacco smoking in lung cancer susceptibility: a systemic review and meta-analysis. Mol Biol Rep 2012; 39: 5769.
  • 6
    Ihsan R, Devi TR, Yadav DS, Mishra AK, Sharma J, Zomawia E, Verma Y, Phukan R, Mahanta J, Kataki AC, Kapur S, Saxena S. Investigation on the role of p53 codon 72 polymorphism and interactions with tobacco, betel quid, and alcohol in susceptibility to cancers in a high-risk population from North East India. DNA Cell Biol 2011; 30: 16371.
  • 7
    Berz D, Wanebo H. Targeting the growth factors and angiogenesis pathways: small molecules in solid tumors. J Surg Oncol 2011; 103: 57486.
  • 8
    Olaussen KA, Planchard D, Adam J, Soria JC. DNA repair pathways and non-small cell lung cancer: clinical perspectives. Bull Cancer 2011; 98: 30522.
  • 9
    Shi G, Cai L, Jiang W, Sui G. Effects of navelbine and docetaxel on gene expression in human lung cancer cell lines. Cell Biochem Biophys 2011; 61: 66571.
  • 10
    Lu J, Hu Z, Wei S, Wang LE, Liu Z, El-Naggar AK, Sturgis EM, Wei Q. A novel functional variant (−842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity. Carcinogenesis 2009; 30: 171721.
  • 11
    Chen D, Song S, Lu J, Luo Y, Yang Z, Huang Q, Fu X, Fan X, Wei Y, Wang J, Wang L. Functional variants of −1318T > G and −673C > T in c-Jun promoter region associated with increased colorectal cancer risk by elevating promoter activity. Carcinogenesis 2011; 32: 10439.
  • 12
    Shaulian E. AP-1—the Jun proteins: oncogenes or tumor suppressors in disguise? Cell Signal 2010; 22: 8949.
  • 13
    Vaiopoulos AG, Papachroni KK, Papavassiliou AG. Colon carcinogenesis: learning from NF-kappaB and AP-1. Int J Biochem Cell Biol 2010; 42: 10615.
  • 14
    Railo A, Nagy II, Kilpelainen P, Vainio S. Wnt-11 signaling leads to down-regulation of the Wnt/beta-catenin, JNK/AP-1 and NF-kappaB pathways and promotes viability in the CHO-K1 cells. Exp Cell Res 2008; 314: 238999.
  • 15
    Lee SY, Lee HS, Moon JS, Kim JI, Park JB, Lee JY, Park MJ, Kim J. Transcriptional regulation of Zic3 by heterodimeric AP-1(c-Jun/c-Fos) during Xenopus development. Exp Mol Med 2004; 36: 46875.
  • 16
    Xiao L, Lang W. A dominant role for the c-Jun NH2-terminal kinase in oncogenic ras-induced morphologic transformation of human lung carcinoma cells. Cancer Res 2000; 60: 4008.
  • 17
    Kather H, Simon B. Adenylate cyclase of human fat cell ghosts. Stimulation of enzyme activity by prostaglandins. J Cyclic Nucleotide Res 1977; 3: 199206.
  • 18
    Bouillet P, Strasser A. BH3-only proteins—evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death. J Cell Sci 2002; 115: 156774.
  • 19
    Ahmed SU, Milner J. Basal cancer cell survival involves JNK2 suppression of a novel JNK1/c-Jun/Bcl-3 apoptotic network. PLoS One 2009; 4: e7305.
  • 20
    Green JA, Elkington PT, Pennington CJ, Roncaroli F, Dholakia S, Moores RC, Bullen A, Porter JC, Agranoff D, Edwards DR, Friedland JS. Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and activator protein-1-dependent monocyte networks. J Immunol 2010; 184: 6492503.
  • 21
    Rutz S, Mordmuller B, Sakano S, Scheffold A. Notch ligands Delta-like1, Delta-like4 and Jagged1 differentially regulate activation of peripheral T helper cells. Eur J Immunol 2005; 35: 244351.
  • 22
    Cohn MA, Hjelmso I, Wu LC, Guldberg P, Lukanidin EM, Tulchinsky EM. Characterization of Sp1, AP-1, CBF and KRC binding sites and minisatellite DNA as functional elements of the metastasis-associated mts1/S100A4 gene intronic enhancer. Nucleic Acids Res 2001; 29: 333546.
  • 23
    Angel P, Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1991; 1072: 12957.
  • 24
    Zhang X, Gamble MJ, Stadler S, Cherrington BD, Causey CP, Thompson PR, Roberson MS, Kraus WL, Coonrod SA. Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells. PLoS Genet 2011; 7: e1002112.
  • 25
    Han CY, Hien TT, Lim SC, Kang KW. Role of Pin1 in UVA-induced cell proliferation and malignant transformation in epidermal cells. Biochem Biophys Res Commun 2011; 410: 6874.
  • 26
    Schreiber M, Kolbus A, Piu F, Szabowski A, Mohle-Steinlein U, Tian J, Karin M, Angel P, Wagner EF. Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev 1999; 13: 60719.
  • 27
    Bos TJ, Margiotta P, Bush L, Wasilenko W. Enhanced cell motility and invasion of chicken embryo fibroblasts in response to Jun over-expression. Int J Cancer 1999; 81: 40410.
  • 28
    Chinenov Y, Kerppola TK. Close encounters of many kinds: Fos–Jun interactions that mediate transcription regulatory specificity. Oncogene 2001; 20: 243852.
  • 29
    de Sousa SO, Mesquita RA, Pinto DS, Jr, Gutkind S. Immunolocalization of c-Fos and c-Jun in human oral mucosa and in oral squamous cell carcinoma. J Oral Pathol Med 2002; 31: 7881.
  • 30
    Maeno K, Masuda A, Yanagisawa K, Konishi H, Osada H, Saito T, Ueda R, Takahashi T. Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers. Oncogene 2006; 25: 2717.
  • 31
    Smeal T, Hibi M, Karin M. Altering the specificity of signal transduction cascades: positive regulation of c-Jun transcriptional activity by protein kinase A. EMBO J 1994; 13: 600610.
  • 32
    Shi CS, Leonardi A, Kyriakis J, Siebenlist U, Kehrl JH. TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related. J Immunol 1999; 163: 327985.
  • 33
    Swenson WG, Wuertz BR, Ondrey FG. Tobacco carcinogen mediated up-regulation of AP-1 dependent pro-angiogenic cytokines in head and neck carcinogenesis. Mol Carcinog 2011; 50: 66879.
  • 34
    Yiin JH, Silver SR, Daniels RD, Zaebst DD, Seel EA, Kubale TL. A nested case-control study of lung cancer risk and ionizing radiation exposure at the portsmouth naval shipyard. Radiat Res 2007; 168: 3418.
  • 35
    Lu J, Yang L, Zhao H, Liu B, Li Y, Wu H, Li Q, Zeng B, Wang Y, Ji W, Zhou Y. The polymorphism and haplotypes of PIN1 gene are associated with the risk of lung cancer in southern and eastern chinese populations. Hum Mutat 2011; 32: 1299308.
  • 36
    Yang L, Li Y, Ling X, Liu L, Liu B, Xu K, Bin X, Ji W, Lu J. A common genetic variant (97906C>A) of DAB2IP/AIP1 is associated with an increased risk and early onset of lung cancer in Chinese males. PLoS One 2011; 6: e26944.
  • 37
    Nakamura Y, Romberger DJ, Tate L, Ertl RF, Kawamoto M, Adachi Y, Mio T, Sisson JH, Spurzem JR, Rennard SI. Cigarette smoke inhibits lung fibroblast proliferation and chemotaxis. Am J Respir Crit Care Med 1995; 151: 1497503.
  • 38
    Blasiak J, Trzeciak A, Malecka-Panas E, Drzewoski J, Wojewodzka M. In vitro genotoxicity of ethanol and acetaldehyde in human lymphocytes and the gastrointestinal tract mucosa cells. Toxicol In Vitro 2000; 14: 28795.
  • 39
    Uh HW, Mertens BJ, Jan van der Wijk H, Putter H, van Houwelingen HC, Houwing-Duistermaat JJ. Model selection based on logistic regression in a highly correlated candidate gene region. BMC Proc 2007; 1( suppl 1): S114.
  • 40
    Wacholder S, Chanock S, Garcia-Closas M, El Ghormli L, Rothman N. Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst 2004; 96: 43442.
  • 41
    Lasham A, Lindridge E, Rudert F, Onrust R, Watson J. Regulation of the human fas promoter by YB-1, Puralpha and AP-1 transcription factors. Gene 2000; 252: 113.
  • 42
    Yanti, Lee M, Kim D, Hwang JK. Inhibitory effect of panduratin A on c-Jun N-terminal kinase and activator protein-1 signaling involved in Porphyromonas gingivalis supernatant-stimulated matrix metalloproteinase-9 expression in human oral epidermoid cells. Biol Pharm Bull 2009; 32: 17705.
  • 43
    Hettinger K, Vikhanskaya F, Poh MK, Lee MK, de Belle I, Zhang JT, Reddy SA, Sabapathy K. c-Jun promotes cellular survival by suppression of PTEN. Cell Death Differ 2007; 14: 21829.
  • 44
    Young MR, Li JJ, Rincon M, Flavell RA, Sathyanarayana BK, Hunziker R, Colburn N. Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion. Proc Natl Acad Sci USA 1999; 96: 982732.
  • 45
    Zhang Y, Pu X, Shi M, Chen L, Qian L, Song Y, Yuan G, Zhang H, Yu M, Hu M, Shen B, Guo N. c-Jun, a crucial molecule in metastasis of breast cancer and potential target for biotherapy. Oncol Rep 2007; 18: 120712.
  • 46
    Spitz MR, Hong WK, Amos CI, Wu X, Schabath MB, Dong Q, Shete S, Etzel CJ. A risk model for prediction of lung cancer. J Natl Cancer Inst 2007; 99: 71526.
  • 47
    Ganesh B, Sushama S, Monika S, Suvarna P. A case-control study of risk factors for lung cancer in Mumbai, India. Asian Pac J Cancer Prev 2011; 12: 35762.
  • 48
    Oliva J, Bardag-Gorce F, Li J, French BA, French SW. S-adenosylmethionine prevents the up regulation of Toll-like receptor (TLR) signaling caused by chronic ethanol feeding in rats. Exp Mol Pathol 2011; 90: 23943.
  • 49
    Bak MJ, Jeong JH, Kang HS, Jin KS, Jun M, Jeong WS. Stimulation of activity and expression of antioxidant enzymes by solvent fractions and isolated compound from Cedrela sinensis leaves in HepG2 cells. J Med Food 2011; 14: 40512.