Childhood leukemia around French nuclear power plants—The geocap study, 2002–2007

Authors

  • Claire Sermage-Faure,

    1. INSERM U1018, CESP Center for research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Villejuif F-94807, Paris, France
    2. Université Paris-Sud, UMRS1018, F-94807, Villejuif, Paris, France
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  • Dominique Laurier,

    1. Institute of Radiological Protection and Nuclear Safety, IRSN/DRPH/SRBE, Fontenay-aux-Roses F-92262, Cedex, France
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  • Stéphanie Goujon-Bellec,

    1. INSERM U1018, CESP Center for research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Villejuif F-94807, Paris, France
    2. Université Paris-Sud, UMRS1018, F-94807, Villejuif, Paris, France
    3. French National Registry of Childhood Hematological malignancies (NRCH), Villejuif F-94807, Paris, France
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  • Michel Chartier,

    1. Institute of Radiological Protection and Nuclear Safety, IRSN/DRPH/SER, F-92262, Fontenay-aux-Roses, France
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  • Aurélie Guyot-Goubin,

    1. INSERM U1018, CESP Center for research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Villejuif F-94807, Paris, France
    2. Université Paris-Sud, UMRS1018, F-94807, Villejuif, Paris, France
    3. French National Registry of Childhood Hematological malignancies (NRCH), Villejuif F-94807, Paris, France
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  • Jérémie Rudant,

    1. INSERM U1018, CESP Center for research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Villejuif F-94807, Paris, France
    2. Université Paris-Sud, UMRS1018, F-94807, Villejuif, Paris, France
    3. French National Registry of Childhood Hematological malignancies (NRCH), Villejuif F-94807, Paris, France
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  • Denis Hémon,

    1. INSERM U1018, CESP Center for research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Villejuif F-94807, Paris, France
    2. Université Paris-Sud, UMRS1018, F-94807, Villejuif, Paris, France
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  • Jacqueline Clavel

    Corresponding author
    1. INSERM U1018, CESP Center for research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Villejuif F-94807, Paris, France
    2. Université Paris-Sud, UMRS1018, F-94807, Villejuif, Paris, France
    3. French National Registry of Childhood Hematological malignancies (NRCH), Villejuif F-94807, Paris, France
    • CESP Equipe 6, INSERM U1018, 16 av. Paul Vaillant-Couturier, F-94807 Villejuif, Cedex, France
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    • Tel.: +33-1-45-59-5037, Fax: +33-1-45-59-5151


Abstract

The aim of this work is to study the risk of childhood acute leukemia (AL) around French nuclear power plants (NPPs). The nationwide Geocap case–control study included the 2,753 cases diagnosed in mainland France over 2002–2007 and 30,000 contemporaneous population controls. The last addresses were geocoded and located around the 19 NPPs. The study used distance to NPPs and a dose-based geographic zoning (DBGZ), based on the estimated dose to bone marrow related to NPP gaseous discharges. An odds ratio (OR) of 1.9 [1.0–3.3], based on 14 cases, was evidenced for children living within 5 km of NPPs compared to those living 20 km or further away, and a very similar association was observed in the concomitant incidence study (standardized incidence ratio (SIR) = 1.9 [1.0–3.2]). These results were similar for all the 5-year-age groups. They persisted after stratification for several contextual characteristics of the municipalities of residence. Conversely, using the DBGZ resulted in OR and SIR close to one in all of the dose categories. There was no increase in AL incidence over 1990–2001 and over the entire 1990–2007 period. The results suggest a possible excess risk of AL in the close vicinity of French NPPs in 2002–2007. The absence of any association with the DBGZ may indicate that the association is not explained by NPP gaseous discharges. Overall, the findings call for investigation for potential risk factors related to the vicinity of NPP and collaborative analysis of multisite studies conducted in various countries.

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