• 1
    Smith J, Lindsay L, Hoots B, et al. Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update. Int J Cancer 2007; 121: 62132.
  • 2
    Wheeler C, Hunt W, Joste N, et al. Human papillomavirus genotype distributions: implications for vaccination and cancer screening in the United States. J Natl Cancer Inst 2009; 101: 47587.
  • 3
    Ho G, Bierman R, Beardsley L, et al. Natural history of cervicovaginal papillomavirus infection in young women. N Engl J Med 1998; 338: 4238.
  • 4
    McCredie M, Sharples K, Paul C, et al. Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study. Lancet Oncol 2008; 9: 42534.
  • 5
    Schiffman M, Wentzensen N, Wacholder S, et al. Human papillomavirus testing in the prevention of cervical cancer. J Natl Cancer Inst 2011; 103: 36883.
  • 6
    Kalantari M, Garcia-Carranca A, Morales-Vazquez CD, et al. Laser capture microdissection of cervical human papillomavirus infections: copy number of the virus in cancerous and normal tissue and heterogeneous DNA methylation. Virology 2009; 390: 26167.
  • 7
    Ding D, Chiang M, Lai H, et al. Methylation of the long control region of HPV16 is related to the severity of cervical neoplasia. Eur J Obstet Gynecol Reprod Biol 2009; 147: 21520.
  • 8
    Kalantari M, Calleja-Macias IE, Tewari D, et al. Conserved methylation patterns of human papillomavirus type 16 DNA in asymptomatic infection and cervical neoplasia. J Virol 2004; 78: 1276272.
  • 9
    Bhattacharjee B, Sengupta S. CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2. Virology 2006; 354: 2805.
  • 10
    Sun C, Reimers L, Burk R. Methylation of HPV16 genome CpG sites is associated with cervix precancer and cancer. Gynecol Oncol 2011; 121: 5963.
  • 11
    Brandsma J, Sun Y, Lizardi PM, et al. Distinct human papillomavirus type 16 methylomes in cervical cells at different stages of premalignancy. Virology 2009; 389: 10007.
  • 12
    Mirabello L, Sun C, Ghosh A, et al. Methylation of human papillomavirus type 16 genome and risk of cervical precancer in a Costa Rican population. JNCI 2012; 104: 55665.
  • 13
    Fernandez A, Rosales C, Lopez-Nieva P, et al. The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer. Genome Res 2009; 19: 43851.
  • 14
    Hublarova P, Hrstka R, Rotterova P, et al. Prediction of human papillomavirus 16 E6 gene expression and cervical intraepithelial neoplasia progression by methylation status. Int J Gynecol Cancer 2009; 19: 3215.
  • 15
    Piyathilake C, Macaluso M, Alvarez R, et al. A higher degree of methylation of the HPV 16 E6 gene is associated with a lower likelihood of being diagnosed with cervical intraepithelial neoplasia. Cancer 2011; 117: 95763.
  • 16
    Herrero R, Schiffman M, Bratti C, et al. Design and methods of a population-based natural history study of cervical neoplasia in a rural province of Costa Rica: the Guanacaste Project. Rev Panam Salud Publica 1997; 1: 36275.
  • 17
    Bratti M, Rodríguez A, Schiffman M, et al. Description of a seven-year prospective study of human papillomavirus infection and cervical neoplasia among 10000 women in Guanacaste, Costa Rica. Rev Panam Salud Publica 2004; 15: 7589.
  • 18
    Vasiljevic N, Wu K, Brentnall A, et al. Absolute quantitation of DNA methylation of 28 candidate genes in prostate cancer using pyrosequencing. Dis Markers 2011; 30: 15161.
  • 19
    Cricca M, Morselli-Labate AM, Venturoli S, et al. Viral DNA load, physical status and E2/E6 ratio as markers to grade HPV16 positive women for high-grade cervical lesions. Gynecol Oncol 2007; 106: 54957.
  • 20
    Benjamini Y, Yekutieli D. The control of the false discovery rate in multiple testing under dependency. Annal Stat 2001; 29: 116588.
  • 21
    McClish D. Analyzing a portion of the ROC curve. Med Decis Making 1989; 9: 19095.
  • 22
    Badal V, Chuang L, Tan E, et al. CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progression. J Virol 2003; 77: 622734.
  • 23
    Wentzensen N, Bergeron C, Cas F, et al. Triage of women with ASCUS and LSIL cytology: use of qualitative assessment of p16INK4a positive cells to identify patients with high-grade cervical intraepithelial neoplasia. Cancer 2007; 111: 5866.
  • 24
    Tsoumpou I, Arbyn M, Kyrgiou M, et al. p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis. Cancer Treat Rev 2009; 35: 21020.
  • 25
    Denton K, Bergeron C, Klement P, et al., European CINtec Cytology Study Group. The sensitivity and specificity of p16(INK4a) cytology vs. HPV testing for detecting high-grade cervical disease in the triage of ASC-US and LSIL pap cytology results. Am J Clin Pathol 2010; 134: 1221.
  • 26
    ASCUS-LSIL Traige Study (ALTS) Group. Results of a randomized trial on the management of cytology interpretations of atypical squamous cells of undetermined significance. Am J Obstet Gynecol 2003; 188: 138392.
  • 27
    Arbyn M, Sasieni P, Meijer C, et al. Chapter 9: clinical applications of HPV testing: a summary of meta-analyses. Vaccine 2006; 24: 7889.
  • 28
    Wright J, Rader J, Davila R, et al. Human papillomavirus triage for young women with atypical squamous cells of undetermined significance. Obstet Gynecol 2006; 107: 8229.