Epidemiology

Coffee consumption and risk of gastric and pancreatic cancer—A prospective cohort study†

  1. Siamak Bidel1,2,‡,*,
  2. Gang Hu1,3,
  3. Pekka Jousilahti2,
  4. Eero Pukkala4,5,
  5. Timo Hakulinen5,
  6. Jaakko Tuomilehto1,2,6,7

Article first published online: 1 SEP 2012

DOI: 10.1002/ijc.27773

Issue

International Journal of Cancer

International Journal of Cancer

Volume 132, Issue 7, pages 1651–1659, 1 April 2013

Additional Information

How to Cite

Bidel, S., Hu, G., Jousilahti, P., Pukkala, E., Hakulinen, T. and Tuomilehto, J. (2013), Coffee consumption and risk of gastric and pancreatic cancer—A prospective cohort study. Int. J. Cancer, 132: 1651–1659. doi: 10.1002/ijc.27773

Author Information

  1. 1

    Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland

  2. 2

    Department of Health Promotion and Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

  3. 3

    Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA

  4. 4

    Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland

  5. 5

    School of Public Health, University of Tampere, Tampere, Finland

  6. 6

    South Ostrobothnia Central Hospital, Seinäjoki, Finland

  7. 7

    Department of Clinical and Preventive Medicine, Danube-University Krems, Krems, Austria

  1. ‡

    Tel: 358919127340, Fax: +358-9-19127313

*Department of Public Health, University of Helsinki, P.O. Box 41 (Mannerheimintie 172, 6 krs), FIN-00014 University of Helsinki, Finland

  1. †

    This study is evaluating the association between coffee consumption and risk of gastric and pancreatic cancer among Finns, whose coffee consumption is the highest in the world. In this large prospective study with a long period of follow-up coffee consumption was not associated with the risk of gastric and/or pancreatic cancers.

  2. ‡

    Tel: 358919127340, Fax: +358-9-19127313

Publication History

  1. Issue published online: 28 JAN 2013
  2. Article first published online: 1 SEP 2012
  3. Accepted manuscript online: 13 AUG 2012 02:28AM EST
  4. Manuscript Accepted: 23 JUL 2012
  5. Manuscript Received: 24 JAN 2012

Funded by

  • Juho Vainio foundation

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Keywords:

  • coffee;
  • gastric cancer;
  • pancreatic cancer;
  • prospective cohort

Abstract

Only few prospective studies have examined the association between coffee consumption and risk of gastric and pancreatic cancer. This study is designed to evaluate this relationship among Finns, whose coffee consumption is the highest in the world. A total of 60,041 Finnish men and women who were 26–74 years of age and without history of any cancer at baseline were included in the present analyses. Coffee consumption and other study parameters were determined at baseline using standardized measurements. Participants were prospectively followed up for onset of gastric and/or pancreatic cancer, emigration, death or until June 30, 2006. During a mean follow-up period of 18 years, 299 cases of gastric cancer and 235 cases of pancreatic cancer were found. There was a nonsignificant inverse association between coffee consumption and risk of gastric cancer among men but not in the women. The multivariate-adjusted hazard ratio of stomach and pancreatic cancer incidence for ≥10 cups of coffee per day compared with nondrinkers were 0.75 (95% CI, 0.40–1.41) (P for trend = 0.19) and 0.82 (95% CI, 0.38–1.76) (P for trend = 0.95) for the combined population of men and women, respectively. We did not find a significant association between coffee consumption and the risk of gastric and/or pancreatic cancers.

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