RUNX family: Regulation and diversification of roles through interacting proteins

Authors

  • Linda Shyue Huey Chuang,

    1. Cancer Science Institute of Singapore, National University of Singapore, Singapore
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  • Kosei Ito,

    1. Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan
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  • Yoshiaki Ito

    Corresponding author
    1. Cancer Science Institute of Singapore, National University of Singapore, Singapore
    2. Institute of Molecular and Cell Biology, Proteos, Singapore
    • Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive #12-01, Singapore 117599, Singapore
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    • Tel.: +65-6516-2242, Fax: +65-6873-9664


Abstract

The Runt-related transcription factors (RUNX) belong to an ancient family of metazoan genes involved in developmental processes. Through multiple protein-interacting partners, RUNX proteins have been implicated in diverse signaling pathways and cellular processes. The frequent inactivation of RUNX genes in cancer indicates crucial roles for RUNX in tumor suppression. This review discusses the abilities of RUNX proteins, in particular RUNX3, to integrate oncogenic signals or environmental cues and to initiate appropriate tumor suppressive responses.

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