Incidence of lymphoplasmacytic lymphoma/Waldenström's macroglobulinaemia in Japan and Taiwan population-based cancer registries, 1996–2003

Authors

  • Masako Iwanaga,

    Corresponding author
    1. Graduate School of Public Health, Teikyo University, Tokyo, Japan
    2. Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan
    • Correspondence to: Masako Iwanaga, MD, MPH, Graduate School of Public Health, Teikyo University, Tokyo, Japan, Tel.: +81-3-3964-1211, Fax: +81-3-3964-1058, E-mail: masakoiwng@gmail.com

    Search for more papers by this author
  • Chun-Ju Chiang,

    1. Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    2. Taiwan Cancer Registry, Taipei, Taiwan
    Search for more papers by this author
  • Midori Soda,

    1. Department of Epidemiology, Nagasaki Laboratory, Radiation Effects Research Foundation, Nagasaki, Japan
    Search for more papers by this author
  • Mei-Shu Lai,

    1. Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    2. Taiwan Cancer Registry, Taipei, Taiwan
    Search for more papers by this author
  • Ya-Wen Yang,

    1. Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    2. Taiwan Cancer Registry, Taipei, Taiwan
    Search for more papers by this author
  • Yasushi Miyazaki,

    1. Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan
    Search for more papers by this author
  • Keitaro Matsuo,

    1. Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Search for more papers by this author
  • Tomohiro Matsuda,

    1. Cancer Information Services and Surveillance Division, Center for Cancer Control and Information Services, National Cancer Center, Tokyo, Japan
    Search for more papers by this author
  • Tomotaka Sobue

    1. Division of Environmental Medicine and Population Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan
    Search for more papers by this author

Abstract

Few studies have investigated the incidence rate of lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia (LPL/WM) in Asian populations. We assessed the incidence of LPL/WM using data from 13 population-based cancer registries in Japan and data from the Taiwan National Cancer registry. During 1996–2003, a total of 280 new cases of LPL/WM were recorded in Japan and 56 were recorded in Taiwan, with the median age at diagnosis being 73 and 67 years, respectively. The incidence of LPL/WM showed male predominance in both countries. Crude age-specific incidence rates increased sharply with age in both countries, especially in people >65 years. Age-standardized (to the World standard population) incidence rates per 100,000 person-years were 0.043 (0.071 for men and 0.023 for women) and 0.031 (0.041 for men and 0.020 for women) in Japan and Taiwan, respectively. Age-standardized (to the 2,000 US standard population) incidence rates in Japan and Taiwan were lower than rates reported in the literature for Asians living in the United State. A significant increasing trend was observed in the incidence over the period from 1996 to 2003 in Japan alone. This report suggests that both environmental and/or genetic factors may be involved in LPL/WM development.

Ancillary