Occurrence of fetoprotein in patients with neoplasms and non-neoplastic diseases

Authors

  • J. Masopust,

    1. Research Institute for Child Development, Prague, University Children's Hospital, Prague, and Department of Gynecology and Obstetrics, School of Medicine, Pilsen, Czechoslovakia
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  • K. Kithier,

    1. Research Institute for Child Development, Prague, University Children's Hospital, Prague, and Department of Gynecology and Obstetrics, School of Medicine, Pilsen, Czechoslovakia
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  • J. Rádl,

    1. Research Institute for Child Development, Prague, University Children's Hospital, Prague, and Department of Gynecology and Obstetrics, School of Medicine, Pilsen, Czechoslovakia
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  • J. Koutecký,

    1. Research Institute for Child Development, Prague, University Children's Hospital, Prague, and Department of Gynecology and Obstetrics, School of Medicine, Pilsen, Czechoslovakia
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  • L. Kotál

    1. Research Institute for Child Development, Prague, University Children's Hospital, Prague, and Department of Gynecology and Obstetrics, School of Medicine, Pilsen, Czechoslovakia
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Abstract

Sera from 248 patients, children and adults with various tumors, and from 484 patients with different non-tumorous diseases, were examined for the presence of fetoprotein by immunochemical methods and specific anti-fetal protein antiserum absorbed with serum of adult individuals. The results show that fetoprotein appears in two types of tumors only: 1) in hepatocellular carcinoma, and 2) in malignant undifferentiated teratoma. In other types of neoplasms including embryonal tumors composed of more or less differentiated tissue, as well as in cases of nephroblastoma, sympathicoblastoma, chorionepithelioma and dysgerminoma, fetoprotein was not detected in any patient. Fetoprotein can occur in the first year of life in some patients suffering from hepatitis or some other liver disease. However, its concentration is low and it has a tendency to disappear with the regression of the disease. Fetoprotein was not detected, however, in patients suffering from non-malignant diseases, including hepatitis, after the first year of life.

Abstract

PRÉSENCE DES PROTÉINES FœTALES CHEZ LES CANCÉREUX ET LES SUJETS ATTEINTS DE MALADIES NON NÉOPLASIQUES

On a recherché la présence de protéines fœtales dans le sérum de 248 enfants et adultes atteints de diverses tumeurs et de 484 sujets atteints de différentes maladies non néoplasiques; on a utilisé à cette fin des méthodes immunochimiques et un sérum spécifique anti-protéines fœtales absorbé par le sérum de sujets adultes. Les résultats montrent que ces protéines n'apparaissent qu'avec deux types de tumeurs: 1) épithélioma à cellules hépatiques; 2) tératome malin indifférencié. Dans les autres types de tumeurs, y compris les tumeurs embryonnaires composées de tissu plus ou moins différencié, ainsi que dans les cas de néphroblastome, sympathoblastome, chorio-épithéliome et dysgerminome, on n'a décelé de protéines fœtales chez aucun malade. Les protéines fœtales peuvent s'observer au cours de la première année chez certains sujets souffrant d'hépatite ou d'une autre maladie du foie. Toutefois, leur concentration est faible et elles ont tendance à disparaǐtre parallèlement à la régression de la maladie. En revanche, on n'a pas décelé de protéines fœtales chez les sujets ǎgés de plus d'un an qui étaient atteints de maladies non malignes, y compris l'hépatite.

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