Lung carcinoma induction in BD rats after a single intratracheal instillation of an arsenic-containing pesticide mixture formerly used in vineyards


  • Dedicated to Prof. H. Druckrey on the occasion of his 75th birthday.


A single intratracheal 0.1-ml instillation of a calcium-arsenate containing vineyard pesticide induced multi-focal bronchogenic adenocarcinomas and bronchiolar-alveolar-cell carcinomas in nine out of 15 treated BD rats. This seems to be the first experimental confirmation of carcinogenicity of arsenic-containing pesticides used formerly in vineyards.