Macrophage content and immunogenicity of C57BL/6J and BALB/cByJ methylcholanthrene-induced sarcomas

Authors

  • Robert Evans,

    1. The Jackson Laboratory, Bar Harbor, Maine 04609; and Michigan Cancer Center, Meyer L. Prentis Cancer Center, 110 E. Warren Avenue, Detroit, Michigan, USA
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  • Ellen M. Lawler

    1. The Jackson Laboratory, Bar Harbor, Maine 04609; and Michigan Cancer Center, Meyer L. Prentis Cancer Center, 110 E. Warren Avenue, Detroit, Michigan, USA
    Current affiliation:
    1. Michigan Cancer Center, Meyer L. Prentis Cancer Center, 110 E. Warren Avenue, Detroit, Michigan 48201
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Abstract

A total of 33 methylcholanthrene-induced sarcomas, growing in C57BL/6J or BALB/cByJ mice, were tested for their immunogenicity and for their relative mac-rophage content. No relationship was demonstrated between these two characteristics. These results suggest that the direct correlation between macrophage content and immunogenicity demonstrated in rat tumor model systems may not hold for other systems.

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