Kinetics of the immune response of tumor-bearing hamsters to two simian virus 40 coded non-structural polypeptides present in simian virus 40 tumor cells

Authors

  • Janet H. Ransom,

    1. Department of Microbiology and Specialized Cancer Research Center, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA.
    Current affiliation:
    1. National Cancer Institute, Bethesda, MD 20205
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  • David L. Thompson,

    1. Department of Microbiology and Specialized Cancer Research Center, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA.
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  • Satvir S. Tevethia

    Corresponding author
    1. Department of Microbiology and Specialized Cancer Research Center, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA.
    • Department of Microbiology and Specialized Cancer Research Center, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
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Abstract

The kinetics of the immune response of hamsters transplanted with virus-free SV40 tumor cells (TSV5) to two SV40-coded non-structural proteins of 94,000 daltons (T antigen) and 17,000 daltons (t antigen) was studied in order to determine if the variation in the immune reactivity of serum from tumor-bearing animals towards these proteins can be explained on the basis of differential immune response during various stages of tumor growth. The results demonstrate that individual animals vary in their capacity to respond immunologically to T and t antigens in SV40-transformed cells and that, further, the immune response to T and t antigens is influenced by the stage of tumor development.

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