Cytogenetic abnormalities in human ependymomas

Authors

  • M. R. Stratton,

    1. Sections of Chemical Carcinogenesis and Pathology, Institute of Cancer Research, Chester Beatty Laboratories, Fulham Road, London, SW3 6JB; and Haddow Laboratories, 15 Cotswold Road, Belmont, Sutton, Surrey, SM2 5NG
    2. Department of Neuropathology, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF
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  • J. Darling,

    1. Gough Cooper Department of Neurological Surgery, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
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  • P. L. Lantos,

    1. Department of Neuropathology, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF
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  • C. S. Cooper,

    1. Sections of Chemical Carcinogenesis and Pathology, Institute of Cancer Research, Chester Beatty Laboratories, Fulham Road, London, SW3 6JB; and Haddow Laboratories, 15 Cotswold Road, Belmont, Sutton, Surrey, SM2 5NG
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  • B. R. Reeves

    1. Sections of Chemical Carcinogenesis and Pathology, Institute of Cancer Research, Chester Beatty Laboratories, Fulham Road, London, SW3 6JB; and Haddow Laboratories, 15 Cotswold Road, Belmont, Sutton, Surrey, SM2 5NG
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Abstract

The karyotypes of 4 human ependymomas have been determined. In one ependymoma, translocations involving chromosomes 9, 17 and 22 were observed together with the loss of the normal chromosome 17. A second ependymoma had many chromosomal alterations that included a translocation between chromosomes 1 and 2 and re-arrangements involving chromosome 17. No major consistent alterations were detected in the remaining 2 cases. Our karyotypes do not resemble the few previously published karyotypes of ependymomas, but had features, such as the alterations involving chromosome 17, that were similar to those of other brain tumours in children.

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