Are energy and energy-providing nutrients related to exocrine carcinoma of the pancreas?

Authors

  • H. B. Bueno De Mesquita,

    Corresponding author
    1. Department of Epidemiology, National Institute of Public Health and Environmental Protection, PO Box 1, 3720 BA Bilthoven, The Netherlands
    • Department of Epidemiology, National Institute of Public Health and Environmental Protection, PO Box 1, 3720 BA Bilthoven, The Netherlands
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  • C. J. Moerman,

    1. Department of Epidemiology, National Institute of Public Health and Environmental Protection, PO Box 1, 3720 BA Bilthoven, The Netherlands
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  • S. Runia,

    1. Department of Dietetics, The Utrecht University Hospital, PO Box 85500, 3508 GA Utrecht, The Netherlands (formerly Department of Epidemiology, National Institute of Public Health and Environmental Protection, Bilthoven, Netherlands)
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  • P. Maisonneuve

    1. Unit of Analytical Epidemiology, International Agency for Research on Cancer, 150 Cours Albert-Thomas, 69372 Lyon Cedex 08, France
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Abstract

During 1984-88 a population-based case-control study was carried out in The Netherlands in collaboration with the International Agency for Research on Cancer in order to further explore the possible relationship between diet and exocrine pancreatic carcinoma. Past habitual dietary intake was assessed in 164 cases and 480 controls. This is the first series of population-based studies of pancreas cancer to perform a comprehensive assessment of diet. The results of logistic regression analysis, controlled for age, gender and total cigarette consumption, suggested a positive association with past habitual intake of energy in directly interviewed patients (OR highest versus lowest quintile 3.35; 95% confidence interval 1.51-7.18). No indication of an effect of Queteler index was found. When maximum-weight-ever-achieved was used, non-significantly reduced risks were observed for the upper 4 quintiles of “maximum” Quetelet index. After controlling for age, gender, response status and total cigarette consumption, a positive relationship with habitual past intake of total carbohydrates was observed (OR 2.40; 95% confidence interval 1.44-3.99). The effect decreased considerably when the analysis was restricted to subjects who reported stable long-term dietary intake. After controlling for age, gender, total cigarette consumption and response status, a significant, positive association between pancreatic cancer and past habitual intake of simple sugars was found (OR 1.95; 95% confidence interval 1.24-3.07). Among those who reported stable longterm dietary intake, no effect was seen. The positive effect of simple sugars was present in males only (OR 2.15; 95% confidence interval 1.18-3.93) and was smaller in men who reported long-term stable dietary intake. Our findings suggest that the development of exocrine pancreatic carcinoma is positively related to past habitual intake of total energy, total carbohydrates and simple sugars, whereas no relationship with body-mass index was observed.

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