Benign breast disease and breast cancer: A case-control study in a cohort in italy
Article first published online: 17 JUL 2006
Copyright © 1991 Wiley-Liss, Inc., A Wiley Company
International Journal of Cancer
Volume 47, Issue 5, pages 703–706, 12 March 1991
How to Cite
Palli, D., Turco, M. R. D., Simoncini, R. and Bianchi, S. (1991), Benign breast disease and breast cancer: A case-control study in a cohort in italy. Int. J. Cancer, 47: 703–706. doi: 10.1002/ijc.2910470513
- Issue published online: 17 JUL 2006
- Article first published online: 17 JUL 2006
- Manuscript Revised: 20 NOV 1990
- Manuscript Received: 19 SEP 1990
- „Lega per la Lotta contro i Tumori”, Florence.
Sixty-two cases of invasive breast cancer were identified in a large cohort of women previously treated for biopsy-proven benign breast disease (BBD) at the Breast Unit of CSPO, in Florence, along with a group of 315 controls, strictly matched by age and year of diagnosis. A pathologist reviewed and reclassified all the original BBD slides according to recently proposed criteria (no evidence of epithelial proliferation, epithelial proliferation without or with atypia). Information about potential confounding factors was collected during personal interviews. In comparison to the women with „non-proliferative” BBD, women classified as having „proliferative disease without atypia” showed a weak and non-significant increase in risk (OR 1.3; 95% CI: 0.5-3.5). In contrast, women with „atypical hyperplasia” were at very high risk of developing breast cancer (OR 13.0; 95% CI: 4.1-41.7). When planning mammography screening or other large-scale early-diagnosis programmes for breast cancer in the general female population, follow-up of high-risk subgroups of BBD patients should be considered.