Butyric monosaccharide ester-induced cell differentiation and anti-tumor activity in mice. Importance of their prolonged biological effect for clinical applications in cancer therapy

Authors

  • Philippe Pouillart,

    Corresponding author
    1. Laboratoire de Recherche contre les Virus, Institut National de la Santé et de la Recherche Médicale, Unité 43, Hǒpital Saint Vincent-de-Paul, 74 avenue Denfert Rochereau, Paris 75014
    2. Laboratoire de Chimie Organique et Cinétique, Université de Picardie, 33 rue Saint Leu, Amiens 80000, France
    • Laboratoire d'Immunophannacologie Expérimentale, Centre National de la Recherche Scientifique, Unité 405, Institut Biomédical des Cordeliers, 15 rue de l'Ecole de Médecine, Paris 75270, France
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  • Italina Cerutti,

    1. Laboratoire de Recherche contre les Virus, Institut National de la Santé et de la Recherche Médicale, Unité 43, Hǒpital Saint Vincent-de-Paul, 74 avenue Denfert Rochereau, Paris 75014
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  • Gino Ronco,

    1. Laboratoire de Chimie Organique et Cinétique, Université de Picardie, 33 rue Saint Leu, Amiens 80000, France
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  • Pierre Villa,

    1. Laboratoire de Chimie Organique et Cinétique, Université de Picardie, 33 rue Saint Leu, Amiens 80000, France
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  • Charles Chany

    1. Laboratoire de Recherche contre les Virus, Institut National de la Santé et de la Recherche Médicale, Unité 43, Hǒpital Saint Vincent-de-Paul, 74 avenue Denfert Rochereau, Paris 75014
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Abstract

The interest of butyric salts is based on their capacity to promote differentiation of malignant cells and inhibition of tumor development. The phenotypic modifications are rapidly reversible and require the continuous presence of butyric salts in the target area, which raises problems for therapeutic applications. We show here that the covalent binding of n-butyric acid on natural polyhydroxylated compounds such as monosaccharides, especially 3- or 6-O-butanoyl- 1,2-O-iropro-pylidene-α-D-glucofuranose, retains the majority of the biological properties of n-butyric acid. The delayed degradation of these covalent compounds is associated with an improved maintenance of cell differentiation and anti-tumor protection in mice. These butyric complexes thus seem potentially useful for therapeutic applications.

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