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Abstract

Human T-cell-leukemia-virus-type-1 (HTLV-I) infection is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-1 -associated myelopathy (HAM)/tropical spastic paraparesis (TSP). The T-cell-targeting immunosuppressants, FK506 and cyclosporin A (CsA), suppressed proliferation of the HAM/TSP-derived T-cell lines, H89–59, H89–79 and H109. FK506 and CsA also reduced expression of the proto-oncogenes, c-myc and c-fos, but not c-jun and interleukin-2-receptor-α (IL-2Rα) gene in H109 cells. The growth-inhibitory effects of FKS06 and CsA were not abrogated by interleukin 2 (IL-2). These results suggest that the inhibitory effects of FK506 and CsA are independent of IL-2, and are associated with the reduction of c-myc and c-fos gene expression.