Bladder cancer and seroreactivity to BK, JC and Merkel cell polyomaviruses: The Spanish bladder cancer study (pages 597–603)
Claudia Robles, Raphael Viscidi, Nuria Malats, Debra T Silverman, Adonina Tardon, Reina Garcia-Closas, Consol Serra, Alfredo Carrato, Jesús Herranz, Josep Lloreta, Nathaniel Rothman, Francisco X. Real, Silvia de Sanjose and Manolis Kogevinas
Article first published online: 27 FEB 2013 | DOI: 10.1002/ijc.28053
The recent classification of Merkel cell polyomavirus (MCV) infection as probably carcinogenic and of BK virus (BKV) and JC virus (JCV) infections as possibly carcinogenic suggests that these agents may play a role in the development of certain malignancies. In this evaluation, which focused on bladder cancer specifically, disease was found to be associated with high seroreactivity for BKV and MCV but not JCV. There was no association of seroreactivity with disease stage or grade. The results suggest that urothelial cell carcinoma, the most common type of bladder cancer in industrialized countries, may have an infectious etiology.