Mechanisms of oral carcinogenesis induced by dibenzo[a,l]pyrene: An environmental pollutant and a tobacco smoke constituent (pages 1300–1309)
Kun-Ming Chen, Joseph B. Guttenplan, Shang-Min Zhang, Cesar Aliaga, Timothy K. Cooper, Yuan-Wan Sun, Joseph DelTondo, Wieslawa Kosinska, Arun K. Sharma, Kun Jiang, Richard Bruggeman, Kwangmi Ahn, Shantu Amin and Karam El-Bayoumy
Version of Record online: 22 APR 2013 | DOI: 10.1002/ijc.28152
Tobacco smoking is the most important carcinogen in the development of oral cancer but molecular studies are hampered by the lack of an adequate animal model. The authors addressed this issue by developing a novel animal model that demonstrates the potent carcinogenicity of (±)-anti-DB[a,l]PDE, a metabolite of the tobacco smoke constituent dibenzo[a,l]pyrene in the oral cavity of mice. They demonstrate that this model is an appropriate platform to explore genetic and epigenetic alterations that can account for the development of oral squamous cell carcinoma. The model may also serve to evaluate the chemopreventive efficacy of agents, which modulate critical molecular mediators such as p53 or COX-2 involved in oral carcinogenesis.