Genetic variants in fas signaling pathway genes and risk of gastric cancer (pages 822–831)
Paula L. Hyland, Shih-Wen Lin, Nan Hu, Han Zhang, Lemin Wang, Hua Su, Chaoyu Wang, Ti Ding, Ze-Zhong Tang, Jin-Hu Fan, You-Lin Qiao, Xiaoqin Xiong, William Wheeler, Carol Giffen, Kai Yu, Jeff Yuenger, Laurie Burdett, Zhaoming Wang, Stephen J. Chanock, Margaret A. Tucker, Sanford M. Dawsey, Neal D. Freedman, Alisa M. Goldstein, Christian C. Abnet and Philip R. Taylor
Article first published online: 11 SEP 2013 | DOI: 10.1002/ijc.28415
The bacteria H. pylori is known to cause gastric cancer, but genetic changes can also contribute, particularly in high-risk populations. Identifying these genetic changes in patients could help clinicians make more accurate prognosis of gastric cancer. These authors looked at variation in genes of the Fas signaling pathway, searching for a connection with GC in a high-risk Chinese population. They found that changes in ten specific genes contributed to GC risk in the population, suggesting further work to investigate the functions of those genes.