Time trends of human papillomavirus types in invasive cervical cancer, from 1940 to 2007 (pages 88–95)
Laia Alemany, Silvia de Sanjosé, Sara Tous, Wim Quint, Carlos Vallejos, Hai-Rim Shin, Luis E. Bravo, Patricia Alonso, Marcus A. Lima, Núria Guimerà, JoEllen Klaustermeier, Antonio Llombart-Bosch, Elena Kasamatsu, Silvio A. Tatti, Ana Felix, Carla Molina, Julio Velasco, Belen Lloveras, Omar Clavero, Enrique Lerma, Jan Laco, Ignacio G. Bravo, Rosa Guarch, Adela Pelayo, Jaume Ordi, Miguel Andújar, Gloria I. Sanchez, Xavier Castellsagué, Nubia Muñoz, F. Xavier Bosch and on Behalf of the RIS HPV TT Study Group
Version of Record online: 30 DEC 2013 | DOI: 10.1002/ijc.28636
Evaluation of the success or failure of human papillomavirus (HPV) vaccination programs depends in part on knowledge of the historical contribution of the different HPV types to human cancer. The present study analyzed HPV type-specific relative contributions to invasive cervical cancer (ICC) over a 70-year period prior to the implementation of HPV vaccination. The relative contributions of different HPV types, including those for which a vaccine is now available, were found to be constant across decades. The findings indicate that HPV vaccination will have a high, stable impact on cervical cancer reduction.