DNA methylation profiling of well-differentiated thyroid cancer uncovers markers of recurrence free survival (pages 598–610)
Veronika Mancikova, Raquel Buj, Esmeralda Castelblanco, Lucía Inglada-Pérez, Anna Diez, Aguirre A. de Cubas, Maria Curras-Freixes, Francisco Xavier Maravall, Didac Mauricio, Xavier Matias-Guiu, Manel Puig-Domingo, Ismael Capel, María Rosa Bella, Enrique Lerma, Eva Castella, Jordi Lluis Reverter, Miguel Ángel Peinado, Mireia Jorda and Mercedes Robledo
Article first published online: 13 JAN 2014 | DOI: 10.1002/ijc.28703
Follicular cell-derived carcinomas of the thyroid gland, which are the most common endocrine malignancies, are of special interest for molecular research, given their common cellular origin. However, whether epigenetic modifications contribute to the heterogeneous nature of follicular thyroid malignancies remains unclear. Here, genome-wide characterization of DNA methylation patterns of well-differentiated thyroid tumors shows that tumors with distinct subtypes and mutational status have unique methylation profiles, offering insight into the biology underlying the heterogeneity and differential outcomes of thyroid cancers. Novel markers associated with recurrence-free survival were also identified and could be used for patient classification.