Review

Translating Nature’s Library: The Bryostatins and Function-Oriented Synthesis

  1. Paul A. Wender*,
  2. Brian A. Loy,
  3. Adam J. Schrier

Article first published online: 24 MAR 2011

DOI: 10.1002/ijch.201100020

Issue

Israel Journal of Chemistry

Israel Journal of Chemistry

Special Issue: Total Synthesis of Natural Products

Volume 51, Issue 3-4, pages 453–472, April 2011

Additional Information

How to Cite

Wender, P. A., Loy, B. A. and Schrier, A. J. (2011), Translating Nature’s Library: The Bryostatins and Function-Oriented Synthesis. Isr. J. Chem., 51: 453–472. doi: 10.1002/ijch.201100020

Author Information

  1. Department of Chemistry, Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA phone: +1 650 723-0208 fax: +1 650 725-0259

*Department of Chemistry, Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA phone: +1 650 723-0208 fax: +1 650 725-0259

Publication History

  1. Issue published online: 8 APR 2011
  2. Article first published online: 24 MAR 2011
  3. Manuscript Accepted: 22 FEB 2011
  4. Manuscript Received: 7 FEB 2011

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Keywords:

  • AIDS;
  • Alzheimer’s disease;
  • bryostatin;
  • function-oriented synthesis;
  • protein kinase C (PKC)

Abstract

We review in part our computational, design, synthesis, and biological studies on a remarkable class of compounds and their designed analogs that have led to preclinical candidates for the treatment of cancer, a first-in-class approach to Alzheimer’s disease, and a promising strategy to eradicate HIV/AIDS. Because these leads target, in part, protein kinase C (PKC) isozymes, they have therapeutic potential even beyond this striking set of therapeutic indications. This program has given rise to new synthetic methodology and represents an increasingly important direction of synthesis focused on achieving function through synthesis-informed design (function-oriented synthesis).

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