Review

Molecular Recognition of Amino Acids, Peptides, and Proteins by Cucurbit[n]uril Receptors

  1. Adam R. Urbach*,
  2. Vijayakumar Ramalingam

Article first published online: 15 APR 2011

DOI: 10.1002/ijch.201100035

Issue

Israel Journal of Chemistry

Israel Journal of Chemistry

Special Issue: Cucurbiturils

Volume 51, Issue 5-6, pages 664–678, May 2011

Additional Information

How to Cite

Urbach, A. R. and Ramalingam, V. (2011), Molecular Recognition of Amino Acids, Peptides, and Proteins by Cucurbit[n]uril Receptors. Isr. J. Chem., 51: 664–678. doi: 10.1002/ijch.201100035

Author Information

  1. Department of Chemistry, Trinity University, 1 Trinity Place, San Antonio, TX, 78212, USA phone: +1 210-999-7660 fax: +1 210-999-7569

*Department of Chemistry, Trinity University, 1 Trinity Place, San Antonio, TX, 78212, USA phone: +1 210-999-7660 fax: +1 210-999-7569

Publication History

  1. Issue published online: 24 MAY 2011
  2. Article first published online: 15 APR 2011
  3. Manuscript Accepted: 27 MAR 2011
  4. Manuscript Received: 6 MAR 2011

Funded by

  • Welch Foundation. Grant Number: W-1640
  • National Science Foundation. Grant Number: CHE-0748483

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (1134K)

Keywords:

  • aqueous;
  • host–guest systems;
  • sequence-specific;
  • site-specific;
  • water chemistry

Abstract

At the forefront of the endeavor to understand and manipulate living systems is the design and study of receptors that bind with high affinity and selectivity to specific amino acids, peptides, and proteins. Cucurbit[n]urils are among the most promising class of synthetic receptors for these targets due to their high affinities and selectivities in aqueous media and to the unique combination of electrostatic and hydrophobic interactions that govern binding. The fundamental supramolecular chemistry in this area has been explored in depth, and novel, useful applications are beginning to emerge.

View Full Article (HTML) Get PDF (1134K)