Why Are Biological Systems Homochiral?
Article first published online: 14 NOV 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Israel Journal of Chemistry
Special Issue: Origins, Transfer, and Amplifications of Chirality
Volume 51, Issue 10, pages 1107–1117, November 2011
How to Cite
Percec, V. and Leowanawat, P. (2011), Why Are Biological Systems Homochiral?. Isr. J. Chem., 51: 1107–1117. doi: 10.1002/ijch.201100152
- Issue published online: 18 NOV 2011
- Article first published online: 14 NOV 2011
- Manuscript Received: 30 OCT 2011
- National Science Foundation. Grant Numbers: DMR-0548559, DMR-0520020, DMS-0935165, DMR-1066116, DMR-1120901
Self-assembling and self-organizable dendrons, dendrimers, and dendronized polymers produce chiral supramolecular architectures that have been developed as biological mimics. Here we review our work on the self-assembly of homochiral, heterochiral, and racemic dendritic dipeptides, and address one of the most fundamental questions of biological systems: Why are biological systems homochiral and not heterochiral or racemic and, if they were heterochiral or racemic, how would they look and function by comparison with contemporary homochiral biological systems?