K. C. Nicolaou and Robert J. Aversa
The cover picture shows the molecular structure of maitotoxin, its producer organism (dinoflagellate Gambierdiscustoxicus), and its carrier (surgeonfish Ctenochaetusstriatus). With a molecular weight of 3422 Daltons, 32 rings, and 99 elements of isomerism, maitotoxin is the largest and most complex secondary metabolite known to date. (Image credits. Dinoflagellate: Dr. Steve Morton, NOAA; Surgeonfish: iStockphoto.com/©Shaun Lombard). The cover was contributed by K. C. Nicolaou (see Maitotoxin: An Inspiration for Synthesis, Nicolaou et al., p. 359 in this issue).