Modeling hippocampal theta oscillation: Applications in neuropharmacology and robot navigation

Authors

  • Tamás Kiss,

    Corresponding author
    1. Department of Biophysics, KFKI Research Institute for Particle and Nuclear Physics of the Hungarian Academy of Sciences, Budapest, Hungary
    • Department of Biophysics, KFKI Research Institute for Particle and Nuclear Physics of the Hungarian Academy of Sciences, Budapest, Hungary
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  • Gergő Orbán,

    1. Department of Biophysics, KFKI Research Institute for Particle and Nuclear Physics of the Hungarian Academy of Sciences, Budapest, Hungary
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  • Péter Érdi

    1. Department of Biophysics, KFKI Research Institute for Particle and Nuclear Physics of the Hungarian Academy of Sciences, Budapest, Hungary
    2. Center for Complex Systems Studies, Physics Department, Kalamazoo College, Kalamazoo, Michigan, USA
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Abstract

This article introduces a biologically realistic mathematical, computational model of theta (≈5 Hz) rhythm generation in the hippocampal CA1 region and some of its possible further applications in drug discovery and in robotic/computational models of navigation. The model shown here uses the conductance-based description of nerve cells: Populations of basket cells, alveus/lacunosum-moleculare interneurons, and pyramidal cells are used to model the hippocampal CA1 and a fast-spiking GABAergic interneuron population for modeling the septal influence. Results of the model show that the septo-hippocampal feedback loop is capable of robust theta rhythm generation due to proper timing of pyramidal cells and synchronization within the basket cell network via recurrent connections. © 2006 Wiley Periodicals, Inc. Int J Int Syst 21: 903–917, 2006.

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