Autophagy as a macrophage response to bacterial infection

Authors

  • Lan Gong,

    1. Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Vic., Australia
    2. ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton Campus, Vic., Australia
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  • Rodney J. Devenish,

    1. Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Vic., Australia
    2. ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton Campus, Vic., Australia
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  • Mark Prescott

    Corresponding author
    1. Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Vic., Australia
    • Department of Biochemistry and Molecular Biology, Monash University, Clayton campus, Victoria 3800, Australia
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    • Tel: +61-3-9905-3724. Fax: +61-3-9902-9500


Abstract

The macrophage is a key component of host defense mechanisms against pathogens. In addition to the phagocytosis of bacteria and secretion of proinflammatory mediators by macrophages, autophagy, a process involved in turnover of cellular material, is a recently identified component of the immune response to bacterial infection. Despite the bactericidal effect of autophagy, some species of intracellular bacteria are able to survive by using one or more strategies to avoid host autophagic attack. Here, we review the latest findings on the interactions between bacteria and autophagy in macrophages. © 2012 IUBMB Life, 64(9): 740–747, 2012

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