SEARCH

SEARCH BY CITATION

REFERENCES

  • 1
    Frumento, G.,Rotondo, R.,Tonetti, M.,Damonte, G.,Benatti U.,Ferrara G.B. ( 2002) Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase. J. Exp. Med. 196, 459468.
  • 2
    Moffett, J. R. andNamboodiri, M. A. ( 2003) Tryptophan and the immune response. Immunol. Cell. Biol. 81, 247265.
    Direct Link:
  • 3
    Mellor, A. L.,Sivakumar, J.,Chandler, P.,Smith, K.,Molina, H., et al. ( 2001) Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy. Nat. Immunol. 2, 6468.
  • 4
    Munn, D. H.,Sharma, M. D.,Hou, D,Baban, B,Lee J. R., et al. ( 2004) Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. J. Clin. Invest. 114, 280290.
  • 5
    Munn, D. H.,Sharma, M. D.,Lee, J. R.,Jhaver, K. G.,Johnson, T. S., et al. ( 2002) Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 297, 18671870.
  • 6
    Terness, P.,Bauer, T.M.,Röse, L.,Dufter, C.,Watzlik, A.,Simon, H.,Opelz, G., et al. ( 2002) Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites. J. Exp. Med. 196, 447457.
  • 7
    Werner, E. R.,Bitterlich, G.,Fuchs, D.,Hausen, A,Reibnegger, G., et al. ( 1987) Human macrophages degrade tryptophan upon induction by interferon-gamma. Life Sci. 41, 273280.
  • 8
    Carlin, J. M.,Borden, E. C.,Sondel, P. M., and Byrne, G. I. ( 1989) Interferon-induced indoleamine 2,3-dioxygenase activity in human mononuclear phagocytes. J. Leukoc. Biol. 45, 2934.
  • 9
    Munn, D. H.,Shafizadeh, E.,Attwood, J. T.,Bondarev, I., and Pashine, A., et al. ( 1999) Inhibition of T cell proliferation by macrophage tryptophan catabolism. J. Exp. Med. 189, 13631372.
  • 10
    Kolodziej, L. R.,Paleolog, E. M., andWilliams, R.O. ( 2011) Kynurenine metabolism in health and disease. Amino Acids 41, 11731183.
  • 11
    Munn, D. H.,Sharma, M. D.,Baban, B.,Harding, H. P.,Zhang Y., et al. ( 2005) GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity 22, 633642.
  • 12
    Desvignes, L. andErnst, J. D. ( 2009) Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis. Immunity 31, 974985.
  • 13
    Morita, T.,Saito, K.,Takemura, M.,Maekawa, N.,Fujigaki, S., et al. ( 2001) 3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon-gamma. Ann. Clin. Biochem. 38 (Part 3), 242251.
  • 14
    Taher, Y. A.,Piavaux, B. J. A.,Reneé, G,van Esch, B. C. A. M.,Hofman, G.A., et al. ( 2008) Indoleamine 2,3-dioxygenase-dependent tryptophan metabolites contribute to tolerance induction during allergen immunotherapy in a mouse model. J. Allergy Clin. Immunol. 121, 983991 e2.
  • 15
    Fallarino, F.,Grohmann, U.,Vacca, C.,Bianchi, R.,Orabona, C., et al. ( 2002) T cell apoptosis by tryptophan catabolism. Cell Death Differ. 9, 10691077.
  • 16
    Löb, S.,Königsrainer, A.,Rammensee, H. G.,Opelz, G.,Terness, P. ( 2009) Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees? Nat. Rev. Cancer 9, 445452.
  • 17
    Baban, B.,Chandler, P. R.,Sharma, M. D.,Pihkala, J.,Koni, P. A., et al. ( 2009) IDO activates regulatory T cells and blocks their conversion into Th17-like T cells. J. Immunol. 183, 24752483.
  • 18
    Sharma, M. D.,Hou, D. Y.,Liu, Y.,Koni, P. A.,Metz, R., et al. ( 2009) Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes. Blood 113, 61026111.
  • 19
    Belladonna, M. L.,Puccetti, P.,Orabona, C.,Fallarino, F.,Vacca C., et al. ( 2007) Immunosuppression via tryptophan catabolism: the role of kynurenine pathway enzymes. Transplantation 84( 1 Suppl), S17S20.
  • 20
    Smolen, J. S. andAletaha, D. ( 2009) Developments in the clinical understanding of rheumatoid arthritis. Arthritis Res. Ther. 11, 204.
  • 21
    Schett, G. ( 2011) Effects of inflammatory and anti-inflammatory cytokines on the bone. Eur. J. Clin. Invest. 41, 13611366.
  • 22
    Drexler, S. K.,Kong, P. L.,Wales, J., and Foxwell, B. M. ( 2008) Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis. Arthritis Res. Ther. 10, 216.
  • 23
    Gutcher, I. andBecher, B. ( 2007) APC-derived cytokines and T cell polarization in autoimmune inflammation. J. Clin. Invest. 117, 11191127.
  • 24
    Sato, K. ( 2008) Th17 cells and rheumatoid arthritis—from the standpoint of osteoclast differentiation. Allergol. Int. 57, 109114.
  • 25
    Zhang, C.,Zhang, J.,Yang, B., and Wu, C. ( 2008) Cyclosporin A inhibits the production of IL-17 by memory Th17 cells from healthy individuals and patients with rheumatoid arthritis. Cytokine 42, 345352.
  • 26
    Zaiss, M. M.,Frey, B.,Hess, A.,Zwerina, J.,Luther, J., et al. ( 2010) Regulatory T cells protect from local and systemic bone destruction in arthritis. J. Immunol. 184, 72387246.
  • 27
    Wright, G. P.,Ehrenstein, M. R., andStauss, H. J. ( 2011) Regulatory T-cell adoptive immunotherapy: potential for treatment of autoimmunity. Expert Rev. Clin. Immunol. 7, 213225.
  • 28
    Schroecksnadel, K.,Kaser, S.,Ledochowski, M.,Neurauter, G.,Mur, E., et al. ( 2003) Increased degradation of tryptophan in blood of patients with rheumatoid arthritis. J. Rheumatol. 30, 19351939.
  • 29
    Schroecksnadel, K.,Winkler, C.,Duftner, C.,Wirleitner, B.,Schirmer, M., et al. ( 2006) Tryptophan degradation increases with stage in patients with rheumatoid arthritis. Clin. Rheumatol. 25, 334337.
  • 30
    de Jong, R. A.,Nijman, H. W.,Boezen, H. M.,Volmer, M.,Ten Hoor, K. A., et al. ( 2011) Serum tryptophan and kynurenine concentrations as parameters for indoleamine 2,3-dioxygenase activity in patients with endometrial, ovarian, and vulvar cancer. Int. J. Gynecol. Cancer 21, 13201327.
  • 31
    Chavele, K. M.,Shukla, D.,Keteepe-Arachi, T.,Seidel, J. A.,Fuchs, D., et al. ( 2010) Regulation of myeloperoxidase-specific T cell responses during disease remission in antineutrophil cytoplasmic antibody-associated vasculitis: the role of Treg cells and tryptophan degradation. Arthritis Rheum. 62, 15391548.
  • 32
    Inglis, J. J.,Criado, G.,Medghalchi, M.,Andrews, M.,Sandison, A., et al. ( 2007) Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen. Arthritis Res. Ther. 9, R113.
  • 33
    Stuart, J. M.,Townes, A. S., andKang, A.H. ( 1982) Nature and specificity of the immune response to collagen in type II collagen-induced arthritis in mice. J. Clin. Invest. 69, 673683.
  • 34
    Criado, G.,Simelyte, E,Inglis, J.J,Essex, D, and Williams R.O. ( 2009) Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis. Arthritis Rheum. 60, 13421351.
  • 35
    Bianco, N. R.,Kim, S. H.,Ruffner, M. A.,Robbins, P. D., et al. ( 2009) Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models. Arthritis Rheum. 60, 380389.
  • 36
    Hara, T.,Yamakura, F.,Takikawa, O.,Hiramatsu, R.,Kawabe, T., et al. ( 2008) Diazotization of kynurenine by acidified nitrite secreted from indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells. J. Immunol. Methods 332, 162169.
  • 37
    Junt, T.,Scandella, E., andLudewig, B. ( 2008) Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defence. Nat. Rev. Immunol. 8, 764775.
  • 38
    Wingender, G.,Garbi, N.,Schumak, B.,Jüngerkes, F.,Endl E., et al. ( 2006) Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO. Eur. J. Immunol. 36, 1220.
  • 39
    Salter, M.,Knowles, R. G., andPogson, C. I. ( 1986) Quantification of the importance of individual steps in the control of aromatic amino acid metabolism. Biochem. J. 234, 635647.
  • 40
    Fallarino, F.,Grohmann U.,You S.,McGrath B. C.,Cavener D. R., et al. ( 2006) The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J. Immunol. 176, 67526761.