Internal friction in enzyme reactions

Authors

  • Anna Rauscher,

    1. Department of Biochemistry, Eötvös University, Budapest, Hungary
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  • Imre Derényi,

    1. Eötvös University, ELTE-HAS “Lendulet” Biophysics Research Group, Budapest, Hungary
    2. Eötvös University, ELTE-HAS Molecular Biophysics Research Group, Budapest, Hungary
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  • László Gráf,

    1. Department of Biochemistry, Eötvös University, Budapest, Hungary
    2. Eötvös University, ELTE-HAS Molecular Biophysics Research Group, Budapest, Hungary
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  • András Málnási-Csizmadia

    Corresponding author
    1. Department of Biochemistry, Eötvös University, Budapest, Hungary
    2. Eötvös University, ELTE-HAS Molecular Biophysics Research Group, Budapest, Hungary
    • András Málnási-Csizmadia, Department of Biochemistry, Eötvös University, Budapest, Hungary
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Errata

This article is corrected by:

  1. Errata: Erratum: Internal friction in enzyme reactions, IUBMB life, 2012, Jan;65(1):35–42 Volume 65, Issue 12, 1043–1044, Article first published online: 20 December 2013

Abstract

The empirical concept of internal friction was introduced 20 years ago. This review summarizes the results of experimental and theoretical studies that help to uncover the nature of internal friction. After the history of the concept, we describe the experimental challenges in measuring and interpreting internal friction based on the viscosity dependence of enzyme reactions. We also present speculations about the structural background of this viscosity dependence. Finally, some models about the relationship between the energy landscape and internal friction are outlined. Alternative concepts regarding the viscosity dependence of enzyme reactions are also discussed. ©2012 IUBMB Life, 65(1):35–42, 2013

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