Amyloid beta accumulation in HIV-1-infected brain: The role of the blood brain barrier

Authors

  • Ibolya E. András,

    Corresponding author
    1. Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, FL, USA
    • Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, 1011 NW 15th Street; Gautier Building, Room 528B, Miami, FL 33136-1019, USA
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    • Tel.: +1-(305)-243-0261

  • Michal Toborek

    1. Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, FL, USA
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Abstract

In recent years, we face an increase in the aging of the HIV-1-infected population, which is not only due to effective antiretroviral therapy but also to new infections among older people. Even with the use of the antiretroviral therapy, HIV-associated neurocognitive disorders represent an increasing problem as the HIV-1-infected population ages. Increased amyloid beta (Aβ) deposition is characteristic of HIV-1-infected brains, and it has been hypothesized that brain vascular dysfunction contributes to this phenomenon, with a critical role suggested for the blood-brain barrier in brain Aβ homeostasis. This review will describe the mechanisms by which the blood-brain barrier may contribute to brain Aβ accumulation, and our findings in the context of HIV-1 infection will be discussed. © 2012 IUBMB Life, 65(1):43–49, 2013

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