• 1
    Massague, J., Blain, S. W., and Lo, R. S. ( 2000) TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 103, 295309.
  • 2
    Whitman, M. ( 1998) Smads and early developmental signaling by the TGFbeta superfamily. Genes Dev. 12, 24452462.
  • 3
    Inman, G. J. ( 2011) Switching TGF beta from a tumor suppressor to a tumor promoter. Curr. Opin. Genet. Dev. 21, 9399.
  • 4
    Massague, J. ( 1998) TGF-beta signal transduction. Annu. Rev. Biochem. 67, 753791.
  • 5
    Bilandzic, M. and Stenvers, K. L. ( 2011) Betaglycan: a multifunctional accessory. Mol. Cell. Endocrinol. 339, 180189.
  • 6
    Lopez-Casillas, F., Wrana, J. L., and Massague, J. ( 1993) Betaglycan presents ligand to the TGF beta signaling receptor. Cell 73, 14351444.
  • 7
    Del Re, E., Babitt, J. L., Pirani, A., Schneyer, A. L., and Lin, H. Y. ( 2004) In the absence of type III receptor, the transforming growth factor (TGF)-beta type II-B receptor requires the type I receptor to bind TGF-beta2. J. Biol. Chem. 279, 2276522772.
  • 8
    Chen, L., Klass, C., and Woods, A. ( 2004) Syndecan-2 regulates transforming growth factor-beta signalling. J. Biol. Chem. 279, 1571515718.
  • 9
    Willems, S. M., Wiweger, M., van Roggen, J. F., and Hogendoorn, P. C. ( 2010) Running GAGs: myxoid matrix in tumor pathology revisited: what's in it for the pathologist? Virchows Arch. 456, 181192.
  • 10
    Berdiaki, A., Nikitovic, D., Tsatsakis, A., Katonis, P., Karamanos, N. K., et al. ( 2009) bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells. Biochim. Biophys. Acta 1790, 12581265.
  • 11
    Fthenou, E., Zong, F., Zafiropoulos, A., Dobra, K., Hjerpe, A., et al. ( 2009) Chondroitin sulfate A regulates fibrosarcoma cell adhesion, motility and migration through JNK and tyrosine kinase signaling pathways. In Vivo 23, 6976.
  • 12
    Spearman, M., Taylor, W. R., Greenberg, A. H., and Wright, J. A. ( 1994) Antisense oligodeoxyribonucleotide inhibition of TGF-beta 1 gene expression and alterations in the growth and malignant properties of mouse fibrosarcoma cells. Gene 149, 2529.
  • 13
    Suzuki, H., Kato, Y., Kaneko, M. K., Okita, Y., Narimatsu, H., et al. ( 2008) Induction of podoplanin by transforming growth factor-beta in human fibrosarcoma. FEBS Lett. 582, 341345.
  • 14
    Berdiaki, A., Zafiropoulos, A., Fthenou, E., Katonis, P., Tsatsakis, A., et al. ( 2008) Regulation of hyaluronan and versican deposition by growth factors in fibrosarcoma cell lines. Biochim. Biophys. Acta 1780, 194202.
  • 15
    Kwak, H. J., Park, M. J., Cho, H., Park, C. M., Moon, S. I., et al. ( 2006) Transforming growth factor-beta1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells. Mol. Cancer Res. 4, 209220.
  • 16
    Sokol, J. P. and Schiemann, W. P. ( 2004) Cystatin C antagonizes transforming growth factor beta signaling in normal and cancer cells. Mol. Cancer Res. 2, 183195.
  • 17
    Rasheed, S., Nelson-Rees, W. A., Toth, E. M., Arnstein, P., and Gardner, M. B. ( 1974) Characterization of a newly derived human sarcoma cell line (HT-1080). Cancer 33, 10271033.
  • 18
    Orosco, A., Fromigue, O., Bazille, C., Entz-Werle, N., Levillain, P., et al. ( 2007) Syndecan-2 affects the basal and chemotherapy-induced apoptosis in osteosarcoma. Cancer Res. 67, 37083715.
  • 19
    Kouvidi, K., Berdiaki, A., Nikitovic, D., Katonis, P., Afratis, N., et al. ( 2011) Role of receptor for hyaluronic acid-mediated motility (RHAMM) in low molecular weight hyaluronan (LMWHA)-mediated fibrosarcoma cell adhesion J. Biol. Chem. 286, 3850938520.
  • 20
    Chalkiadaki, G., Nikitovic, D., Berdiaki, A., Katonis, P., Karamanos, N. K., et al. ( 2011) Heparin plays a key regulatory role via a p53/FAK-dependent signaling in melanoma cell adhesion and migration. IUBMB Life 63, 109119.
  • 21
    Park, H., Han, I., Kwon, H. J., and Oh, E. S. ( 2005) Focal adhesion kinase regulates syndecan-2-mediated tumorigenic activity of HT1080 fibrosarcoma cells. Cancer Res. 65, 98999905.
  • 22
    Whiteford, J. R., Behrends, V., Kirby, H., Kusche-Gullberg, M., Muramatsu, T., et al. ( 2007) Syndecans promote integrin-mediated adhesion of mesenchymal cells in two distinct pathways. Exp. Cell. Res. 313, 39023913.
  • 23
    Whiteford, J. R., Xian, X., Chaussade, C., Vanhaesebroeck, B., Nourshargh, S., et al. ( 2011) Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148. Mol. Biol. Cell. 22, 36093624.
  • 24
    Oh, E. S. and Couchman, J. R. ( 2004) Syndecans-2 and -4; close cousins, but not identical twins. Mol. Cells 17, 181187.
  • 25
    Kähäri, V. M., Peltonen, J., Chen, Y. Q., and Uitto, J. ( 1991) Differential modulation of basement membrane gene expression in human fibrosarcoma HT-1080 cells by transforming growth factor-beta 1. Enhanced type IV collagen and fibronectin gene expression correlates with altered culture phenotype of the cells. Lab. Invest. 64, 807818.
  • 26
    Walsh, M. F., Ampasala, D. R., Rishi, A. K., and Basson, M. D. ( 2009) TGF-beta1 modulates focal adhesion kinase expression in rat intestinal epithelial IEC-6 cells via stimulatory and inhibitory Smad binding elements. Biochim. Biophys. Acta 1789, 8898.
  • 27
    Hauck, C. R., Hsia, D. A., and Schlaepfer, D. D. ( 2002) The focal adhesion kinase—a regulator of cell migration and invasion. IUBMB Life 53, 115119.
  • 28
    Guan, J. L. ( 2010) Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer. IUBMB Life 62, 268276.
  • 29
    Hu, M., Pollock, R. E., and Nicolson, G. L. ( 1997) Purification and characterization of human lung fibroblast motility-stimulating factor for human soft tissue sarcoma cells: identification as an NH2-terminal fragment of human fibronectin. Cancer Res. 57, 35773584.
  • 30
    Cevikbas, F., Schaefer, L., Uhlig, P., Robenek, H., Theilmeier, G., et al. ( 2008) Unilateral nephrectomy leads to up-regulation of syndecan-2- and TGF-beta-mediated glomerulosclerosis in syndecan-4 deficient male mice. Matrix Biol. 27, 4252.
  • 31
    Blobe, G. C., Liu, X., Fang, S. J., How, T., and Lodish, H. F. ( 2001) A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. J. Biol. Chem. 276, 3960839617.
  • 32
    Kusano, Y., Oguri, K., Nagayasu, Y., Munesue, S., Ishihara, M., et al. ( 2000) Participation of syndecan 2 in the induction of stress fiber formation in cooperation with integrin alpha5beta1: structural characteristics of heparan sulfate chains with avidity to COOH-terminal heparin-binding domain of fibronectin. Exp. Cell. Res. 256, 434444.
  • 33
    López-Casillas, F., Payne, H. M., Andres, J. L., and Massagué, J. ( 1994) Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites. J. Cell. Biol. 124, 557568.
  • 34
    Tsutsumi, K., Kasaoka, T., Park, H. M., Nishiyama, H., Nakajima, M., et al. ( 2008) Tumor growth inhibition by synthetic and expressed siRNA targeting focal adhesion kinase. Int. J. Oncol. 33, 215224.
  • 35
    Galante, L. L. and Schwarzbauer, J. E. ( 2007) Requirements for sulfate transport and the diastrophic dysplasia sulfate transporter in fibronectin matrix assembly. J. Cell. Biol. 179, 9991009.