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REFERENCES

  • 1
    Kandeel, F. R., Swerdloff, R. S., and Pryor, J. L. (eds.) ( 2007) Male Reproductive Dysfunction: Pathophysiology and Treatment, Informa Healthcare USA Inc., New York.
  • 2
    Tam, P. P. and Zhou, S. X. ( 1996) The allocation of epiblast cells to ectodermal and germ-line lineages is influenced by the position of the cells in the gastrulating mouse embryo. Dev. Biol. 178, 124132.
  • 3
    Koopman, P. ( 1999) Sry and Sox9: mammalian testis-determining genes. Cell. Mol. Life Sci. 55, 839856.
  • 4
    Western, P. S., Miles, D. C., van den Bergen, J. A., Burton, M., and Sinclair, A. H. ( 2007) Dynamic regulation of mitotic arrest in fetal male germ cells. Stem Cells 26, 339347.
  • 5
    Archambeault, D. R. and Yao, H. H. ( 2010) Activin A, a product of fetal Leydig cells, is a unique paracrine regulator of Sertoli cell proliferation and fetal testis cord expansion. Proc. Natl. Acad. Sci. U. S. A. 107, 1052610531.
  • 6
    Mendis, S., Meachem, S., Sarraj, M., and Loveland, K. L. ( 2010) Activin A balances Sertoli and germ cell proliferation in the fetal mouse testis. Biol. Reprod. 84, 379391.
  • 7
    Hermo, L., Pelletier, R. M., Cyr, D. G., and Smith, C. E. ( 2010) Surfing the wave, cycle, life history and genes/proteins expressed by testicular germ cells. Part 1: background to spermatogenesis, spermatogonia and spermatocytes. Microsc. Res. Tech. 73, 241278.
  • 8
    Kluin, P. M., Kramer, M. F., and de Rooij, D. G. ( 1984) Proliferation of sprematogonia and Sertoli cells in maturing mice. Anat. Embryol. 160, 7378.
  • 9
    Wu, X., Wan, S., and Lee, M. M. ( 2007) Key factors in the regulation of fetal and postnatal Leydig cell development. J. Cell. Physiol. 213, 429433.
  • 10
    Feng, X. H. and Derynck, R. ( 2005) Specificity and versatility in TGFbeta signaling through Smads. Annu. Rev. Cell Dev. Biol. 21, 659693.
  • 11
    Massague, J., Seoane, J., and Wotton, D. ( 2005) Smad transcription factors. Genes Dev. 19, 27832810.
  • 12
    Moustakas, A. and Heldin, C.-H. ( 2009) The regulation of TGFbeta signal transduction. Development 136, 36993714.
  • 13
    Cheng, C. Y. (ed.) ( 2008) Molecular Mechanisms in Spermatogenesis, Landes Bioscience, Austin, TX.
  • 14
    de Rooij, D. G. ( 1998) Stem cells in the testis. Int. J. Exp. Pathol. 79, 6780.
  • 15
    de Rooij, D. G. and Griswold, M. D. ( 2012) Questions about spermatogonia posed and answered since 2000. J. Androl. [Epub ahead of print].
  • 16
    Oatley, M. J., Racicot, K. E., and Oatley, J. M. ( 2011) Sertoli cells dictate spermatogonial stem cell niches in the mouse testis. Biol. Reprod. 84, 639645.
  • 17
    Barakat, B., Itman, C., Mendis, S., and Loveland, K. L. ( 2012) Activins and inhibins in mammalian testis development: new models, new insights. Mol. Cell. Endocrinol. 359, 6677.
  • 18
    Chang, H., Brown, C. W., and Matzuk, M. M. ( 2002) Genetic analysis of the mammalian Transforming growth factor-beta superfamily. Endocr. Rev. 23, L787823.
  • 19
    Itman, C., Mendis, S., Barakat, B., and Loveland, K. L. ( 2006) All in the family: transforming growth factor beta family action in testis development. Reproduction 132, 233246.
  • 20
    Barakat, B., Itman, C., Mendis, S. H., Loveland, K. L. ( 2012) Activins and inhibins in mammalian testis development: new models, new insights. Mol. Cell. Biol. 359, 6677.
  • 21
    Loveland, K. L. and Hime, G. R. ( 2005) TGF-beta superfamily members in spermatogenesis: setting the stage for fertility in the mouse and Drosophila. Cell Tissue Res. 322, 141146.
  • 22
    Shi, Y. and Massague, J. ( 2003) Mechanisms of TGF-beta signalling from cell membrane to the nucleus. Cell Adhes. Commun. 113, 685700.
  • 23
    Moustakis, A. and Heldin, C. H. ( 2005) Non-Smad TGF-beta signals. J. Cell Sci. 118, 35733584.
  • 24
    Sekelsky, J. J., Newfeld, S. J., Raftery, L. A., Chartoff, E. H., and Gelbart, W. M. ( 1995) Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139, 13471358.
  • 25
    Hahn, S. A., Schutte, M., Hogue, A. T., Moskalk, C. A., da Costa, L. T., et al. ( 1996) DPC4, a candidate tumor suppressor gene at human chromosome 18q21.2. Science 271, 350353.
  • 26
    Derynck, R., Gelbart, W. M., Harland, R. M., Heldin, C.-H., Kern, S. E., et al. ( 1996) Nomenclature: vertebrate mediators of TGfbeta family signals. Cell 87, 173.
  • 27
    Mullen, A. C., Orlando, D. A., Newman, J. J., Loven, J., Kumar, R. M., et al. ( 2011) Master transcription factors determine cell-type-specific responses to TGF-beta signaling. Cell 147, 565576.
  • 28
    Yan, X. and Chen, Y.-G. ( 2011) Smad7: not only a regulator, but also a cross-talk mediator of TGFbeta signalling. Biochem. J. 434, 110.
  • 29
    Bakkebo, M., Huse, K., Hilden, V. I., Smeland, E. B., and Oksvold, M. P. ( 2010) TGF-beta-induced growth inhibition in B-cell lymphoma correlates with Smad1/5 signalling and constitutively active p38 MAPK. BMC Immunol. 11, 57.
  • 30
    Daly, A. C., Randall, R. A., and Hill, C. S. ( 2008) Transforming growth factor beta-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth. Mol. Cell. Biol. 28, 68896902.
  • 31
    Liu, I. M., Schilling, S. H., Knouse, K. A., Choy, L., Derynck, R., et al. ( 2008) TGF-beta stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGF-beta switch. EMBO J. 28, 8898.
  • 32
    Barbara, N. P., Wrana, J. L., and Letarte, M. ( 1999) Endoglin is an accessory protein that interacts with the signalling receptor comlex of multiple members of the transforming growth factor-beta superfamily. J. Biol. Chem. 274, 584594.
  • 33
    Onichtchouk, D., Chen, Y.-G., Dosch, R., Gawantka, V., Delius, H., et al. ( 1999) Silencing of TGFbeta signalling by the pseudoreceptor BAMBI. Nature 401, 480485.
  • 34
    Massague, J. ( 2000) How cells read TGF-beta signals. Nat. Rev. 1, 169178.
  • 35
    Conidi, A., Cazzola, S., Beets, K., Coddens, K., Collart, C., et al. ( 2011) Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFb/BMP signaling in vivo. Cytokine Growth Factor Rev. 22, 287300.
  • 36
    Matsuzaki, K. ( 2011) Smad phosphoisoform signaling specificity: the right place at the right time. Carcinogenesis 32, 15781588.
  • 37
    Dias, V., Meachem, S., Rajpert-de Meyts, E., McLachlan, R., Manuelpillai, U., et al. ( 2008) Activin receptor subunits in normal and dysfunctional adult human testis. Hum. Reprod. 23, 412420.
  • 38
    Fragale, A., Puglisi, R., Morena, A. R., Stafanini, M., and Boitani, C. ( 2001) Age-dependent activin receptor expression pinpoints activin A as a physiological regulator of rat Sertoli cell proliferation. Mol. Hum. Reprod. 7, 11071114.
  • 39
    Itman, C. and Loveland, K. L. ( 2008) SMAD expression in the testis: an insight into BMP regulation of spermatogenesis. Dev. Dyn. 237, 97111.
  • 40
    Itman, C., Wong, C., Hunyadi, B., Ernst, M., Jans, D. A., et al. ( 2011) Smad3 regulates androgen responsiveness and influences maturation in the juvenile testis. Endocrinology 152, 20762089.
  • 41
    Wang, R.-A. and Zhao, G.-Q. ( 1999) Transforming growth factor beta signal transducer Smad2 is expressed in mouse meiotic germ cells, Sertoli cells and Leydig cells during spermatogenesis. Biol. Reprod. 61, 9991004.
  • 42
    Zhao, G. Q. and Hogan, B. L. M. ( 1997) Evidence that mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse. Mech. Dev. 61, 6373.
  • 43
    Dias, V. L., Rajpert-de Meyts, E., McLachlan, R., and Loveland, K. L. ( 2009) Analysis of activin/TGFb-signaling modulators within the normal and dysfunctinoal adult human testis reveals evidence of altered signaling capacity in a subset of seminomas. Reproduction 138, 801811.
  • 44
    Itman, C., Whiley, P. A., Zhou, W., Meistrich, M. L., Sahin Z., et al. ( 2009) Regulated production of SnoN2 is a feature of testicular differentiation. Microsc. Res. Tech. 72, 833844.
  • 45
    Itman, C., Wong, C., Whiley, P. A., Fernando, D., and Loveland, K. L. ( 2011) TGF-beta superfamily signalling regulators are differentially expressed in the developing and adult mouse testis. Spermatogenesis 1, 6372.
  • 46
    Arnold, S. J., Maretto, S., Islam, A., Bikoff, E. K., and Robertson, E. J. ( 2006) Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo. Dev. Biol. 296, 104118.
  • 47
    Dunn, N. R., Koonce, C. H., Anderson, D. C., Islam, A., Bikoff, E. K., et al. ( 2005) Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile. Genes Dev. 19, 153163.
  • 48
    Zhu, Y., Richardson, J. A., Parada, L. F., and Graff, J. M. ( 1998) Smad3 mutant mice develop metastatic colorectal cancer. Cell 94, 703707f714.
  • 49
    Aoki, H., Fujii, M., Imamura, T., Yagi, K., Takehara, K., et al. ( 2001) Synergistic effects of different bone morphogenetic protein type I receptors on alkaline phosphatase induction. J. Cell Sci. 114, 14831489.
  • 50
    Hatakeyama, Y., Nguyen, J., Wang, X., Muckolls, G. H., and Shum, L. ( 2003) Smad signaling in mesenchymal and chondroprogenitor cells. J. Bone Joint Surg. Am. 85-A, 1318.
  • 51
    Ying, Y. and Zhao, G. Q. ( 2001) Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell generation in the mouse. Dev. Biol. 232, 484492.
  • 52
    Hayashi, K., Kobayashi, T., Umino, T., Goitsuka, R., Matsui, Y., et al. ( 2002) SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast. Mech. Dev. 118, 99109.
  • 53
    Tremblay, K. D., Dunn, N. R., and Robertson, E. J. ( 2001) Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. Development 128, 36093621.
  • 54
    Chang, H. and Matzuk, M. M. ( 2001) Smad5 is required for mouse primordial germ cell development. Mech. Dev. 104, 6167.
  • 55
    Hayashi, K. K. T., Umino, T., Goitsuka, R., Matsui, Y., and Kitamura, D. ( 2002) SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast. Mech. Dev. 118, 99109.
  • 56
    Chu, G. C., Dunn, N. R., Anderson, D. C., Oxburgh, L., and Robertson, E. J. ( 2004) Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo. Development 131, 35013512.
  • 57
    de Sousa Lopes, S. M., Roelen, B. A., Monteiro, R. M., Emmens, R., Lin, H. Y., et al. ( 2004) BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev. 18, 18391849.
  • 58
    Matzuk, M. M., Kumar, T. R., Vassalli, A., Bickenbach, J. R., Roop, D. R., et al. ( 1995) Functional analysis of activins during mammalian development. Nature 1995, 6520.
  • 59
    Memon, M. A., Anway, M. D., Covert, T. R., Uzumcu, M., and Skinner, M. K. ( 2008) Transforming growth factor beta (TGFb1, TGFb2, TGFb3) null-mutant phenotypes in embryonic gonadal development. Mol. Cell. Endocrinol. 294, 7080.
  • 60
    Richards, A. J., Enders, G. C., and Resnick, J. L. ( 1999) Activin and TGF-beta limit murine primordial germ cell proliferation. Dev. Biol. 207, 470475.
  • 61
    Waldrip, W. R., Bikoff, E. K., Hoodless, P. A., Wrana, J. L., and Robertson, E. J. ( 1998) Smad2 signaling in the extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell 92, 797808.
  • 62
    Li, C.-Y., Guo, Z., and Wang, Z. ( 2007) TGFbeta receptor saxophone non-autonomously regulates the germline proliferation in a Smox/dSmad2-dependent manner in Drosophila testis. Dev. Biol. 309, 7077.
  • 63
    Wilhelm, D., Palmer, S., and Koopman, P. ( 2007) Sex determination and gonadal development in mammals. Physiol. Rev. 87, 128.
  • 64
    Boitani, C., Stefanini, M., Fragale, A., and Morena, A. R. ( 1995) Activin stimulates Sertoli cell proliferation in a defined period of rat testis development. Endocrinology 136, 45385444.
  • 65
    Buzzard, J. J., Farnworth, P. G., de Kretser, D. M., O'Connor, A. E., Wreford, N. G., et al. ( 2003) Proliferative phase Sertoli cells display a developmentally regulated response to activin in vitro. Endocrinology 144, 474483.
  • 66
    Itman, C., Small, C., Griswold, M. D., Nagaraja, A. K., Matzuk, M. M., et al. ( 2009) Developmentally regulated SMAD2 and SMAD3 utilization directs activin signalling outcomes. Dev. Dyn. 238, 16881700.
  • 67
    Luukko, K., Ylikorkala, A., and Makela, T. P. ( 2001) Developmentally regulated expression of Smad3, Smad4, Smad6 and Smad7involved in TGF-beta signaling. Mech. Dev. 101, 209212.
  • 68
    Moreno, S. G., Attali, M., Allemand, I., Messiaen, S., Fouchet, P., et al. ( 2010) TGFbeta signaling in male germ cells regulates gonocyte quiescence and fertility in mice. Dev. Biol. 342, 7484.
  • 69
    Souquet, B., Tourpin, S., Messiaen, S., Moison, D., Habert, R., et al. ( 2012) Nodal signaling regulates the entry into meiosis in fetal germ cells. Endocrinology 153, 24662473.
  • 70
    Ishisaki, A., Yamato, K., Hashimoto, S., Nakao, A., Tamaki, K., et al. ( 1999) Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells. J. Biol. Chem. 274, 1363713642.
  • 71
    Narula, A., Kilen, S., Ma, E., Kroeger, J., Goldberg, E., et al. ( 2002) Smad4 overexpression causes germ cell ablation and Leydig cell hyperplasia in transgenic mice. Am. J. Pathol. 161, 17231734.
  • 72
    Barakat, B., O'Connor, A. E., Gold, E., de Kretser, D. M., and Loveland, K. L. ( 2008) Inhibin, activin, follistatin and follicle stimulating hormone serum levels and testicular production are highly modulated during the first spermatogenic wave in mice. Reproduction 136, 345359.
  • 73
    Mullaney, B. P. and Skinner, M. K. ( 1993) Transforming growth factor-beta (Beta1, Beta2 and Beta3) gene expression and action during pubertal development of the seminiferous tubule: potential role at the onset of spermatogenesis. Mol. Endocrinol. 7, 6776.
  • 74
    Pellegrini, M., Grimaldi, P., Rossi, P., Geremia, R., and Dolci, S. ( 2003) Developmental expression of BMP4/ALK3/SMAD5 signalling pathway in the mouse testis: a potential role of BMP4 in spermatogonia differentiation. J. Cell Sci. 116, 33633372.
  • 75
    Olaso, R., Pairault, C., Boulogne, B., Durand, P., and Habert, R. ( 1998) Transforming growth factor beta1 and beta2 reduce the number of gonocytes by increasing apoptosis. Endocrinology 139, 733740.
  • 76
    Mather, J. P., Attie, K. M., Woodruff, T. K., Rice, G. C., and Phillips, D. M. ( 1990) Activin stimulates spermatogonial proliferation in germ-Sertoli cell cultures from immature rat testis. Endocrinology 127, 32063214.
  • 77
    Li, Q., Graff, J. M., O'Connor, A. E., Loveland, K. L., and Matzuk, M. M. ( 2007) SMAD3 regulates gonadal tumorigenesis. Mol. Endocrinol. 21, 24722486.
  • 78
    Pangas, S. A., Li, X., Umans, L., Zwijsen, A., Huylebroeck, D., et al. ( 2008) Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumour development in mice. Mol. Cell. Biol. 28, 248257.
  • 79
    Zhao, G.-Q., Liaw, L., and Hogan, B. L. M. ( 1998) Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. Development 125, 11031112.
  • 80
    Zhao, G. Q., Deng, K., Labosky, P. A., Liaw, L., and Hogan, B. L. M. ( 1996) The gene encoding bone morphogenetic protein 8B (BMP8B) is required for the initiation and maintenance of spermatogenesis in the mouse. Genes Dev. 10, 16571669.
  • 81
    Zhao, G.-Q., Chen, Y.-X., Liu, X.-M., Xu, Z., and Qi, X. ( 2001) Mutation in Bmp7 exacerbates the phenotype of Bmp8a mutants in spermatogenesis and epididymis. Dev. Biol. 241, 212222.
  • 82
    Hu, J., Chen, Y.-X., Wang, D., Qi, X., Li T.-G., et al. ( 2004) Developmental expression and function of Bmp4 in spermatogenesis and in maintaining epididymal integrity. Dev. Biol. 276, 158171.
  • 83
    Kokkinaki, M., Lee, T.-L., He, Z., Jiang, J., Golestaneh, N., et al. ( 2010) Age affects gene expression in mouse spermatogonial stem/progenitor cells. Reproduction 139, 10111020.
  • 84
    de Bosscher, K., Hill, C. S., and Nicolas, F. J. ( 2004) Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells. Biochem. J. 379, 209216.
  • 85
    Inman, G. J., Nicolas, F. J., and Hill, C. S. ( 2002) Nucleocytoplasmic shuttling of Smads 2,3 and 4 permits sensing of TGF-beta receptor activity. Mol. Cell 10, 283294.
  • 86
    Liu, F., Pouponnot, C., and Massague, J. ( 1997) Dual role of the Smad4/DPC4 tumor suppressor in TGFb-inducible transcriptional compelxes. Genes Dev. 11, 31573167.
  • 87
    Itman, C. and Loveland, K. L. SMAD expression in the testis: an insight into BMP regulation of spermatogenesis. Dev. Dyn. 237, 97111.
  • 88
    Itoh, F., Divecha, N., Brocks, L., Oomen, L., Janssen, H., et al. ( 2002) The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-beta/Smad signalling. Genes Cells 7, 321331.
  • 89
    Goto, D., Nakajima, N., Mori, Y., Kurasawa, K., Kitamura, N., et al. ( 2001) Interaction between Smad anchor for receptor activation and Smad3 is not essential for TGFbeta/Smad3 mediated signaling. Biochem. Biophys. Res. Commun. 281, 11001105.
  • 90
    Runyan, C. E., Schnaper, H. W., and Poncelet, A. C. ( 2005) The role of internalization in transforming growth factor beta 1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cells. J. Biol. Chem. 289, 83008308.
  • 91
    Miura, S., Takeshita, T., Asao, H., Kimura, Y., Murata, K., et al. ( 2000) Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. Mol. Cell. Biol. 20, 93469355.
  • 92
    Xu, J., Beyer, A. R., Walker, W. H., and McGee, E. A. ( 2003) Developmental and stage-specific expression of Smad2 and Smad3 in rat testis. J. Androl. 24, 192200.
  • 93
    Bergmann, M. ( 1987) Photoperiod and testicular function in Phodopus sungorus. Adv. Anat. Embryol. Cell Biol. 105, 176.
  • 94
    Kano, K., Kurohmaru, M., Hayashi, Y., and Taniguchi, K. ( 2001) Effects of short photoperiod on the expression of Smad2 and Smad3 mRNA in Syrian hamster testis. J. Vet. Med. Sci. 63, 2530.
  • 95
    Sheng, X., Zhang, H., Zhang, M., Zhang, W., Hu, X., et al. ( 2012) Seasonal changes in immunoreactivity of activin signaling component proteins in wild ground squirrel testes. J. Reprod. Dev. 58, 126131.
  • 96
    Rajpert-de Meyts, E. and Hoei-Hansen, C. E. ( 2007) From gonocytes to testicular cancer: the role of impaired gonadal development. Ann. N. Y. Acad. Sci. 1120, 168180.
  • 97
    Fustino, N., Rakheja, D., Ateek, C. S., Neumann, J. C., and Amatruda, J. F. ( 2011) Bone morphogenetic protein signalling activity distinguishes histological subsets of paediatric germ cell tumours. Int. J. Androl. 34, e218e233.
  • 98
    Bouras, M., Tabone, E., Bertholon, J., Sommer, P., Bouvier, R., et al. ( 2000) A novel SMAD4 gene mutation in seminoma germ cell tumors. Cancer Res. 60, 922928.
  • 99
    Looyenga, B. D. and Hammer, G. D. ( 2007) Genetic removal of Smad3 from inhibin-null mice attenuates tumor progression by uncoupling extracellular mitogenic signals from the cell cycle machinery. Mol. Endocrinol. 21, 24402457.
  • 100
    de Jong, J., Stoop, H., Gillis, J. M., Hersmus, R., van Gurp, R. J. H. L. M., et al. ( 2008) Further characterization of the first seminoma cell line TCam-2. Genes Chromosomes Cancer 47, 185196.
  • 101
    Nettersheim, D., Westernstroer, B., Haas, N., Leinhaas, A., Brustle, O., et al. ( 2012) Establishment of a versatile seminoma model indicates cellular plasticity of germ cell tumour cells. Genes Chromosomes Cancer 51, 717726.
  • 102
    Young, J. C., Jaiprakash, A., Mithraprabhu, S., Itman, C., Kitazawa, R., et al. ( 2011) TCam-2 seminoma cell line exhibits characteristic foetal germ cell responses to TGF-beta ligands and retinoic acid. Int. J. Androl. 4, E204e217.
  • 103
    Dalgaard, M. D., Weinhold, N., Edsgard, D., Silver, J. D., Pers, T. H., et al. ( 2012) A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation. J. Med. Genet. 49, 5865.
  • 104
    Cools, M., Wolffenbuttel, K. P., Drop, S. L. S., Oosterhuis, J. W., and Looijenga, L. H. J. ( 2011) Gonadal development and tumor formation at the crossroads of male and female sex determination. Sex. Dev. 5, 167180.
  • 105
    National Cancer Institute U.N.I.o.H. ( 2009) Surveillance Epidemiology and End Results. Available at: www.seer.cancer.gov.
  • 106
    Rajpert-de Meyts, E., Toppari, J., Hoi-Hansen, C. E., Muller, J., and Skakkebaek, N. E. ( 2003) Testicular Neoplasia in Childhood and Adolescence, Karger Publishing, Basel, Switzerland.
  • 107
    Young, R. H. ( 2005) Sex cord-stromal tumours of the ovary and testis: their similarities and differences with consideration of selected problems. Mod. Pathol. 18, S81S98.
  • 108
    Young, R. H. ( 2008) Testicular tumours—some new and a few perennial problems. Arch. Pathol. Lab. Med. 132, 548564.
  • 109
    Matzuk, M. M., Finegold, M. J., Su, J. G., Hsueh, A. J., and Bradley, A. ( 1992) Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature 360, 313319.
  • 110
    Rajanahally, S., Agno, J. E., Nalam, R. L., Weinstein, M. B., Loveland, K. L., et al. ( 2010) Genetic evidence that Smad2 is not required for gonadal tumor development in inhibin-deficient mice. Reprod. Biol. Endocrinol. 8, 69.
  • 111
    Griswold, M. D. ( 1998) The central role of Sertoli cells in spermatogenesis. Semin. Cell Dev. Biol. 9, 411416.
  • 112
    McLachlan, R., O'Donnell, L., Meachem, S., Stanton, P. G., de Kretser, D. M., et al. ( 2002) Identification of specific sites of hormonal regulation in spermatogenesis in rats, monkeys and man. Recent Prog. Horm. Res. 57, 149179.
  • 113
    Meachem, S. J., Ruwanpura, S. M., Ziolkowski, J., Ague, J. M., Skinner, M., et al. ( 2005) Developmentally distinct in vivo effects of FSH on proliferation and apoptosis during testis maturation. J. Endocrinol. 186, 429446.
  • 114
    Krishnamurthy, H., Babu, P. S., Morales, C. R., and Sairam, M. R. ( 2001) Delay in sexual maturity of the follicle-stimulating hormone receptor knockout male mouse. Biol. Reprod. 65, 522531.
  • 115
    Wreford, N. G., Kumar, T. R., Matzuk, M. M., and de Kretser, D. M. ( 2001) Analysis of the testicular phenotype of the follicle-stimulating hormone beta-subunit knockout and the activin type II receptor knockout mice by stereological analysis. Endocrinology 142, 29162920.
  • 116
    Kumar, T. R., Palapattu, G., Wang, P., Woodruff, T. K., Boime, I., et al. ( 1999) Transgenic models to study gonadotropin function: the role of follicle-stimulating hormone in gonadal growth and tumorigenesis. Mol. Endocrinol. 13, 851865.
  • 117
    Kumar, T. R., Wang, Y., and Matzuk, M. M. ( 1996) Gonadotropins are essential modifier factors for gonadal tumor development in inhibin-deficient mice. Endocrinology 137, 42104216.
  • 118
    Wang, R.-S., Yeh, S., Tzeng, C.-R., and Chang, C. ( 2009) Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice. Endocr. Rev. 30, 119132.
  • 119
    Tan, K., de Gendt, K., Atanassova, N., Walker, M., Sharpe, R., et al. ( 2005) The role of androgens in Sertoli cell proliferation and functional maturation: studies in mice with total or Sertoli cell-selective ablation of the androgen receptor. Endocrinology 146, 26742683.
  • 120
    Hwang, K., Yatsenko, A. N., Jorgez, C. J., Mukherjee, S., Nalam, R. L., et al. ( 2011) Mendelian genetics of male infertility. Ann. N. Y. Acad. Sci. 1214, E1E17.
  • 121
    Jamsai, D. and O'Bryan, M. K. ( 2011) Mouse models in male fertility research. Asian J. Androl. 13, 139151.
  • 122
    Dennler, S., Andre, J., Alexaki, I., Li, A., Magnaldo, T., et al. ( 2007) Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res. 67, 69816986.
  • 123
    Charbonney, E., Speight, P., Masszi, A., Nakano, H., and Kapus, A. ( 2011) B-catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition. Mol. Cell. Biol. 22, 44724485.
  • 124
    Fujii, M., Toyoda, T., Nakanishi, H., Yatabe, Y., Sato, A., et al. ( 2012) TGFb synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth. J. Exp. Med. 209, 479494.
  • 125
    Cooper, T. G., Noonan, E., von Eckardstein, S., Auger, J., Baker, H. W. G., et al. ( 2010) World Health Organization reference values for human semen characteristics. Hum. Reprod. Update 163, 231245.