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Proteoglycans in the central nervous system: Role in development, neural repair, and Alzheimer's disease
Article first published online: 7 JAN 2013
Copyright © 2013 International Union of Biochemistry and Molecular Biology, Inc.
Volume 65, Issue 2, pages 108–120, February 2013
How to Cite
Cui, H., Freeman, C., Jacobson, G. A. and Small, D. H. (2013), Proteoglycans in the central nervous system: Role in development, neural repair, and Alzheimer's disease. IUBMB Life, 65: 108–120. doi: 10.1002/iub.1118
- Issue published online: 28 JAN 2013
- Article first published online: 7 JAN 2013
- Manuscript Accepted: 20 NOV 2012
- Manuscript Received: 23 OCT 2012
- brain development;
- Alzheimer's disease
Proteoglycans (PGs) are major components of the cell surface and extracellular matrix and play critical roles in development and maintenance of the central nervous system (CNS). PGs are a family of proteins, all of which contain a core protein to which glycosaminoglycan side chains are covalently attached. PGs possess diverse physiological roles, particularly in neural development, and are also implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). The main functions of PGs in the CNS are reviewed as are the roles of PGs in brain injury and in the development or treatment of AD. © 2013 IUBMB Life, 65(2)108–120, 2013.