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Obscurins: Unassuming giants enter the spotlight
Article first published online: 20 MAR 2013
Copyright © 2013 International Union of Biochemistry and Molecular Biology, Inc.
Volume 65, Issue 6, pages 479–486, June 2013
How to Cite
Perry, N. A., Ackermann, M. A., Shriver, M., Hu, L.-Y. R. and Kontrogianni-Konstantopoulos, A. (2013), Obscurins: Unassuming giants enter the spotlight. IUBMB Life, 65: 479–486. doi: 10.1002/iub.1157
- Issue published online: 23 MAY 2013
- Article first published online: 20 MAR 2013
- Manuscript Accepted: 31 JAN 2013
- Manuscript Received: 21 DEC 2012
- striated muscle;
- cardiac hypertrophy;
- breast cancer;
Discovered about a decade ago, obscurin (∼720 kDa) is a member of a family of giant proteins expressed in striated muscle that are essential for normal muscle function. Much of what we understand about obscurin stems from its functions in cardiac and skeletal muscle. However, recent evidence has indicated that variants of obscurin (“obscurins”) are expressed in diverse cell types, where they contribute to distinct cellular processes. Dysfunction or abrogation of obscurins has also been implicated in the development of several pathological conditions, including cardiac hypertrophy and cancer. Herein, we present an overview of obscurins with an emphasis on novel findings that demonstrate their heretofore-unsuspected importance in cell signaling and disease progression. © 2013 IUBMB Life, 65(6):479–486, 2013.