Tel: +39-06-72594811. Fax: +39-06-2023500
The phytotoxin fusicoccin, a selective stabilizer of 14-3-3 interactions?
Article first published online: 9 APR 2013
Copyright © 2013 International Union of Biochemistry and Molecular Biology, Inc.
Volume 65, Issue 6, pages 513–517, June 2013
How to Cite
Camoni, L., Visconti, S. and Aducci, P. (2013), The phytotoxin fusicoccin, a selective stabilizer of 14-3-3 interactions?. IUBMB Life, 65: 513–517. doi: 10.1002/iub.1167
- Issue published online: 23 MAY 2013
- Article first published online: 9 APR 2013
- Manuscript Accepted: 28 FEB 2013
- Manuscript Received: 31 JAN 2013
- 14-3-3 proteins;
- protein-protein interaction;
- drug development
Summary The study of the structure and dynamics of protein–protein interaction networks has become overwhelming in all biological systems. Most of the biological events are the consequence of several protein–protein interactions finely regulated by covalent modifications and physiological effectors. Moreover, several studies have shown that the complex interactome responsible for the progress and control of vital processes is disturbed in diseases. Besides the basic information on the mechanisms involved in the processes driven by protein–protein interactions, it appears nowadays extremely challenging to study possible regulators of the lifespan of protein networks. Small molecules able to stabilize or to inhibit protein complexes could easily find applications as potential innovative drugs. In this article, we hypothesize that a natural product, the fungal phytotoxin fusicoccin, can play a role as a stabilizer of interactions between 14-3-3 proteins and specific natural targets. A very specific stabilizer molecule is the ideal starting point for the development of a family of structurally related drugs able to selectively tune 14-3-3 interaction with their targets. © 2013 IUBMB Life, 65(6):513–517, 2013