Mechanistic insights into the nongenomic regulation of phospholipid synthesizing enzymes
Article first published online: 28 MAY 2013
Copyright © 2013 International Union of Biochemistry and Molecular Biology, Inc.
Volume 65, Issue 7, pages 584–592, July 2013
How to Cite
Cardozo Gizzi, A. M. and Caputto, B. L. (2013), Mechanistic insights into the nongenomic regulation of phospholipid synthesizing enzymes. IUBMB Life, 65: 584–592. doi: 10.1002/iub.1173
- Issue published online: 21 JUN 2013
- Article first published online: 28 MAY 2013
- Manuscript Accepted: 21 MAR 2013
- Manuscript Received: 14 FEB 2013
- membrane biogenesis;
- enzyme mechanisms;
- transcription factors;
- enzyme activity regulation
Lipid synthesis is a complex process regulated at multiple levels. Here, we will discuss nongenomic regulatory mechanisms, particularly the activation and/or recruitment of key enzymes to membranes. The phospholipid synthesis enzymes Lipin and CTP:phosphocholine cytidylyltransferase are taken as examples of these mechanisms that are mediated by posttranslational modifications or by an intrinsic property of the enzyme that senses lipid composition. In addition, special emphasis will be put on another relevant non genomic lipid synthesis regulation mechanism that is dependent on c-Fos, a protein that has deserved less attention so far. This latter regulatory mechanism is emerging as an important determinant for processes that require high rates of lipid synthesis such as those of growth and proliferation. © 2013 IUBMB Life, 65(7):584–592, 2013.