• 1
    Nam, H., Lewis, N. E., Lerman, J., Lee, D. H., Chang, R. L., Kim, D., and Palsson, B. O. (2012). Network context and selection in the evolution to enzyme specificity. Science 337, 11011104.
  • 2
    Weng, J. K. and Noel, J. P. The remarkable pliability and promiscuity of specialized metabolism Cold Spring Harb. Symp. Quant. Biol., DOI: 10.1101/sqb.2012.77.014787.
  • 3
    O'Brien, P. J. and Herschlag, D. (1999). Catalytic promiscuity and the evolution of new enzymatic activities. Chem. Biol. 6, R91R105.
  • 4
    Percudani, R. and Peracchi, A. (2003). A genomic overview of pyridoxal-phosphate-dependent enzymes. EMBO Rep. 4, 850854.
  • 5
    Kontani, Y., Kaneko, M., Kikugawa, M., Fujimoto, S., and Tamaki, N. (1993). Identity of D-3-aminoisobutyrate-pyruvate aminotransferase with alanine-glyoxylate aminotransferase 2. Biochim. Biophys. Acta 1156, 161166.
  • 6
    Cooper, A. J., Krasnikov, B. F., Okuno, E., and Jeitner, T. M. (2003). L-alanine-glyoxylate aminotransferase II of rat kidney and liver mitochondria possesses cysteine S-conjugate β-lyase activity: a contributing factor to the nephrotoxicity/hepatotoxicity of halogenated alkenes? Biochem. J. 376, 169178.
  • 7
    Cooper, A. J., Krasnikov, B. F., Niatsetskaya, Z. V., Pinto, J. T., Callery, P. S., Villar, M. T., Artigues, A., and Bruschi, S. A. (2011). Cysteine S-conjugate beta-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents. Amino Acids 41, 727.
  • 8
    Shao, L. and Vawter, M. P. (2008). Shared gene expression alterations in schizophrenia and bipolar disorder. Biol. Psychiatry 64, 8997.
  • 9
    McQuillin, A., Rizig, M., and Gurling, H. M. (2007). A microarray gene expression study of the molecular pharmacology of lithium carbonate on mouse brain mRNA to understand the neurobiology of mood stabilization and treatment of bipolar affective disorder. Pharmacogenet. Genomics 17, 605617.
  • 10
    Veiga-da-Cunha, M., Hadi, F., Balligand, T., Stroobant, V., and Van Schaftingen, E. (2012). Molecular identification of hydroxylysine kinase and of the ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine. J. Biol. Chem. 287, 72467255.
  • 11
    Schiroli, D. (2011) The brain enzyme AGXT2L1 is a phospho-lyase acting on phosphorylated amines, MS Thesis, University of Parma.
  • 12
    Sprinson, D. B. and Weliky, I. (1969). The conversion of ethanolamine to acetate in mammalian tissues. Biochem. Biophys. Res. Commun. 36, 866870.
  • 13
    Fleshood, H. L. and Pitot, H. C. (1970). The metabolism of O-phosphorylethanolamine in animal tissues. I. O-phosphorylethanolamine phospho-lyase: partial purification and characterization. J. Biol. Chem. 245, 44144420.
  • 14
    Dunlop, D. S. and Neidle, A. (2005). Regulation of serine racemase activity by amino acids. Brain Res. Mol. Brain Res. 133, 208214.
  • 15
    Karsten, W. E. and Cook, P. F. (2002). Detection of intermediates in reactions catalyzed by PLP-dependent enzymes: O-acetylserine sulfhydrylase and serine-glyoxalate aminotransferase. Methods Enzymol. 354, 223237.
  • 16
    Rossi, G. L., Mozzarelli, A., Peracchi, A., and Rivetti, C. (1992). Time course of chemical and structural events in protein crystals measured by microspectrophotometry. Phil. Trans. Royal Soc. Lond. A 340, 191207.
  • 17
    Cooper, A. J. (1983). Biochemistry of sulfur-containing amino acids. Annu. Rev. Biochem. 52, 187222.
  • 18
    Toney, M. D. (2005). Reaction specificity in pyridoxal phosphate enzymes. Arch. Biochem. Biophys. 433, 279287.
  • 19
    Laue, H. and Cook, A. M. (2000). Biochemical and molecular characterization of taurine:pyruvate aminotransferase from the anaerobe Bilophila wadsworthia. Eur. J. Biochem. 267, 68416848.
  • 20
    Mehta, P. K. and Christen, P. (2000). The molecular evolution of pyridoxal-5′-phosphate-dependent enzymes. Adv. Enzymol. 74, 129184.
  • 21
    Jencks, W. P. (1981). On the attribution and additivity of binding energies. Proc. Natl. Acad. Sci. USA 78, 40464050.
  • 22
    Donini, S., Percudani, R., Credali, A., Montanini, B., Sartori, A., and Peracchi, A. (2006). A threonine synthase homolog from a mammalian genome. Biochem. Biophys. Res. Commun. 350, 922928.
  • 23
    Modica-Napolitano, J. S. and Renshaw, P. F. (2004). Ethanolamine and phosphoethanolamine inhibit mitochondrial function in vitro: implications for mitochondrial dysfunction hypothesis in depression and bipolar disorder. Biol. Psychiatry 55, 273277.
  • 24
    Miller, J. et al. (2012). Progressive membrane phospholipid changes in first episode schizophrenia with high field magnetic resonance spectroscopy. Psychiatry Res. 201, 2533.