A network of interorganellar communications underlies cellular aging


Address correspondence to: Vladimir I. Titorenko, Department of Biology, Concordia University, 7141 Sherbrooke Street, West, Montreal, QC, Canada H4B 1R6. E-mail: vladimir.titorenko@concordia.ca


Organelles within a eukaryotic cell respond to age-related intracellular stresses and environmental factors by altering their functional states to generate, direct and process the flow of interorganellar information that is essential for establishing a pro- or antiaging cellular pattern. The scope of this review is to critically analyze recent progress in understanding how various intercompartmental (i.e., organelle–organelle and organelle–cytosol) communications regulate cellular aging in evolutionarily distant eukaryotes. Our analysis suggests a model for an intricate network of intercompartmental communications that underly cellular aging in eukaryotic organisms across phyla. This proposed model posits that the numerous directed, coordinated and regulated organelle–organelle and organelle–cytosol communications integrated into this network define the long-term viability of a eukaryotic cell and, thus, are critical for regulating cellular aging. © 2013 IUBMB Life, 65(8):665–674, 2013