Axin: An emerging key scaffold at the synapse

Authors

  • Yu Chen,

    1. Division of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, China
    2. Guangdong Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen, Guangdong, China
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  • Amy K.Y. Fu,

    1. Division of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, China
    2. Guangdong Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen, Guangdong, China
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  • Nancy Y. Ip

    Corresponding author
    1. Guangdong Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen, Guangdong, China
    • Division of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, China
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  • Abbreviations: β-cat, β-catenin; Δβ-cat, truncated fragment of β-catenin; Scrib, scribble.

*Address correspondence to: Nancy Y. Ip, Division of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. Tel.: +852-2358-7267. Fax: +852-2358-1552. E-mail: boip@ust.hk

Abstract

Neurons communicate through neurotransmission at the synapse. Precise regulation of the synaptic structure and signaling during the formation and remodeling of synapses is vital for information processing between neurons. Scaffold proteins play key roles in synapses by tethering the signaling cascades spatially and temporally to ensure proper brain functioning. This review summarizes the recent evidence indicating that Axin, a scaffold protein, plays a central role in orchestrating presynaptic and postsynaptic signaling complexes to regulate synapse development and plasticity in the central nervous system. © 2013 IUBMB Life, 65(8):685–691, 2013.

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