Abbreviations: β-cat, β-catenin; Δβ-cat, truncated fragment of β-catenin; Scrib, scribble.
Axin: An emerging key scaffold at the synapse
Article first published online: 11 JUL 2013
© 2013 International Union of Biochemistry and Molecular Biology
Volume 65, Issue 8, pages 685–691, August 2013
How to Cite
Chen, Y., Fu, A. K.Y. and Ip, N. Y. (2013), Axin: An emerging key scaffold at the synapse. IUBMB Life, 65: 685–691. doi: 10.1002/iub.1184
- Issue published online: 26 JUL 2013
- Article first published online: 11 JUL 2013
- Manuscript Accepted: 29 APR 2013
- Manuscript Received: 26 MAR 2013
- synaptic plasticity;
- Wnt signaling
Neurons communicate through neurotransmission at the synapse. Precise regulation of the synaptic structure and signaling during the formation and remodeling of synapses is vital for information processing between neurons. Scaffold proteins play key roles in synapses by tethering the signaling cascades spatially and temporally to ensure proper brain functioning. This review summarizes the recent evidence indicating that Axin, a scaffold protein, plays a central role in orchestrating presynaptic and postsynaptic signaling complexes to regulate synapse development and plasticity in the central nervous system. © 2013 IUBMB Life, 65(8):685–691, 2013.