PES1 differentially regulates the expression of ERα and ERβ in ovarian cancer

Authors

  • Jieping Li,

    Corresponding author
    1. Department of Clinic Medical Laboratory, General Hospital of Fujian Corps of CAPF, Fuzhou, China
    • Address correspondence to: Jieping Li, Department of Clinic Medical Lab, General Hospital of Fujian Corps of CAPF, Fuzhou 350003, China. Tel: +86 591 83128221, Fax: +86 59183129106. E-mail: liejieping@hotmail.com or Xiaopeng Lan, Institute of Clinic Lab Medicine, Fuzhou General Hospital of Nanjing Military Command, PLA, Fuzhou 350003, China. Tel & Fax: +86 591 83732529. E-mail: lanxp@sina.com

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  • Qinren Zhuang,

    1. Department of Clinic Medical Laboratory, General Hospital of Fujian Corps of CAPF, Fuzhou, China
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  • Xiaopeng Lan,

    Corresponding author
    1. Institute of Clinic Laboratory Medicine, Fuzhou General Hospital of Nanjing Military Command, PLA, Fuzhou, China
    • Address correspondence to: Jieping Li, Department of Clinic Medical Lab, General Hospital of Fujian Corps of CAPF, Fuzhou 350003, China. Tel: +86 591 83128221, Fax: +86 59183129106. E-mail: liejieping@hotmail.com or Xiaopeng Lan, Institute of Clinic Lab Medicine, Fuzhou General Hospital of Nanjing Military Command, PLA, Fuzhou 350003, China. Tel & Fax: +86 591 83732529. E-mail: lanxp@sina.com

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  • Guobin Zeng,

    1. Department of Clinic Medical Laboratory, General Hospital of Fujian Corps of CAPF, Fuzhou, China
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  • Xuping Jiang,

    1. Department of gynaecology and obstetrics, General Hospital of Fujian Corps of CAPF, Fuzhou, China
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  • Zongming Huang

    1. Department of Pathology, General Hospital of Fujian Corps of CAPF, Fuzhou, China
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Abstract

Estrogen exhibits mitogenic activity in early ovarian carcinogenesis and plays an important role in ovarian tumorigenesis. Due to the increased expression of ERα and decreased expression of the ERβ, the ratio of ERα and ERβ is markedly increased in ovarian cancer. We have recently reported that PES1 regulates the balance of ERα and ERβ at the post-transcriptional level in breast cancer. Here, we report that PES1 inversely regulates the expression of ERα and ERβ in addition to their transcriptional activities in epithelial ovarian cancer. We found that the ablation of PES1 resulted in the significant downregulation of ERα and estrogen-responsive genes such as cylin D1, HIF-1α and VEGF and the up-regulation of ERβ and p21WAF1. Cell proliferation in both tested ovarian cell lines was markedly inhibited and cells were arrested in G2 after PES1 was ablated. Further analysis of clinical samples showed that expression of PES1 correlated positively with ERα expression and negatively with ERβ expression. Our results demonstrate that PES1 may play important role in the progression of ovarian cancer by inversely regulating the ERα and ERβ expression. PES1 may be a new target for ovarian cancer therapy. © 2013 IUBMB Life, 65(12):1017–1025, 2013.

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