Genomic lens on neuroglobin transcription

Authors

  • Santina Cutrupi,

    1. Center for Molecular Systems Biology, University of Turin, Turin, Italy
    2. Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
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  • Giulio Ferrero,

    1. Center for Molecular Systems Biology, University of Turin, Turin, Italy
    2. Department of Computer Science, University of Turin, Turin, Italy
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  • Stefania Reineri,

    1. Bioindustry Park Silvano Fumero, Turin, Italy
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  • Francesca Cordero,

    1. Center for Molecular Systems Biology, University of Turin, Turin, Italy
    2. Department of Computer Science, University of Turin, Turin, Italy
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  • Michele De Bortoli

    Corresponding author
    1. Center for Molecular Systems Biology, University of Turin, Turin, Italy
    2. Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
    • Address correspondence to: Michele De Bortoli, Center for Molecular Systems Biology, University of Turin, Ospedale San Luigi 10043, Orbassano, Turin, Italy. Tel.: +390125561427; E-mail: michele.debortoli@unito.it

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Abstract

Neuroglobin is a brain globin with neuroprotective effects against ischemia and related pathological processes, acting as O2 sensor and antiapoptotic pathway transducer. Here, we survey data on neuroanatomical coexpression of transcription factors, epigenetic signature and predictive transcription factor binding sites at the neuroglobin gene locus to find hints of pathways to neuroglobin transcriptional regulation. These data provide a glimpse of how neuroglobin expression may translate into neuronal diversity and function, as well as disease. © 2014 IUBMB Life, 66(1):46–51, 2014.

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