• 1
    Stow, L. R. and Gumz, M. L. (2011) The circadian clock in the kidney. J. Am. Soc. Nephrol. 22, 598604.
  • 2
    Ko, C. H. and Takahashi, J. S. (2006) Molecular components of the mammalian circadian clock. Hum. Mol. Genet. 15 (Spec No 2), R271R277.
  • 3
    Bass, J. and Takahashi, J. S. (2010) Circadian integration of metabolism and energetics. Science. 330, 13491354.
  • 4
    Kondratov, R. V., Gorbacheva, V. Y., and Antoch, M. P. (2007) The role of mammalian circadian proteins in normal physiology and genotoxic stress responses. Curr. Top. Dev. Biol. 78, 173216.
  • 5
    Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., et al. (2000) Interacting molecular loops in the mammalian circadian clock. Science 288, 10131019.
  • 6
    Reppert, S. M. and Weaver, D. R. (2002) Coordination of circadian timing in mammals. Nature 418, 935941.
  • 7
    DeBruyne, J. P., Weaver, D. R., and Reppert, S. M. (2007) CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat. Neurosci. 10, 543545.
  • 8
    Vitaterna, M. H., King, D. P., Chang, A. M., Kornhauser, J. M., Lowrey, P. L., et al. (1994) Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264, 719725.
  • 9
    Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., et al. (2005) Obesity and metabolic syndrome in circadian Clock mutant mice. Science 308, 10431045.
  • 10
    Yang, S., Liu, A., Weidenhammer, A., Cooksey, R. C., McClain, D., et al. (2009) The role of mPer2 clock gene in glucocorticoid and feeding rhythms. Endocrinology 150, 21532160.
  • 11
    Garcia, J. A., Zhang, D., Estill, S. J., Michnoff, C., Rutter, J., et al. (2000) Impaired cued and contextual memory in NPAS2-deficient mice. Science 288, 22262230.
  • 12
    Chen, Y., Xu, X., Tan, Z., Ye, C., Zhao, Q., et al. (2012) Age-related BMAL1 change affects mouse bone marrow stromal cell proliferation and osteo-differentiation potential. Arch. Med. Sci. 8, 3038.
  • 13
    Shi, S., Hida, A., McGuinness, O. P., Wasserman, D. H., Yamazaki, S., et al. (2010) Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2. Curr. Biol. 20, 316321.
  • 14
    McDearmon, E. L., Patel, K. N., Ko, C. H., Walisser, J. A., Schook, A. C., et al. (2006) Dissecting the functions of the mammalian clock protein BMAL1 by tissue-specific rescue in mice. Science 314, 13041308.
  • 15
    Fu, L., Pelicano, H., Liu, J., Huang, P., and Lee, C. (2002) The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111, 4150.
  • 16
    Bhatwadekar, A. D., Yan, Y., Qi, X., Thinschmidt, J. S., Neu, M. B., et al. (2013) Per2 mutation recapitulates the vascular phenotype of diabetes in the retina and bone marrow. Diabetes 62, 273282.
  • 17
    Lee, S., Donehower, L. A., Herron, A. J., Moore, D. D., and Fu, L. (2010) Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice. PLoS One 5, e10995.
  • 18
    Bell-Pedersen, D., Cassone, V. M., Earnest, D. J., Golden, S. S., Hardin, P. E., et al. (2005) Circadian rhythms from multiple oscillators: lessons from diverse organisms. Nat. Rev. Genet. 6, 544556.
  • 19
    Hayasaka, N., LaRue, S. I., and Green, C. B. (2002) In vivo disruption of Xenopus CLOCK in the retinal photoreceptor cells abolishes circadian melatonin rhythmicity without affecting its production levels. J. Neurosci. 22, 16001607.
  • 20
    Hayasaka, N., LaRue, S. I., and Green, C. B. (2010) Differential contribution of rod and cone circadian clocks in driving retinal melatonin rhythms in Xenopus. PLoS One 5, e15599.
  • 21
    Storch, K. F., Paz, C., Signorovitch, J., Raviola, E., Pawlyk, B., et al. (2007) Intrinsic circadian clock of the mammalian retina: importance for retinal processing of visual information. Cell 130, 730741.
  • 22
    Ruan, G. X., Gamble, K. L., Risner, M. L., Young, L. A., and McMahon, D. G. (2012) Divergent roles of clock genes in retinal and suprachiasmatic nucleus circadian oscillators. PLoS One 7, e38985.
  • 23
    Bray, M. S. and Young, M. E. (2009) The role of cell-specific circadian clocks in metabolism and disease. Obes. Rev. 10 (Suppl 2), 613.
  • 24
    Fuller, P. M., Lu, J., and Saper, C. B. (2008) Differential rescue of light- and food-entrainable circadian rhythms. Science 320, 10741077.
  • 25
    Pendergast, J. S., Nakamura, W., Friday, R. C., Hatanaka, F., Takumi, T., et al. (2009) Robust food anticipatory activity in BMAL1-deficient mice. PLoS One 4, e4860.
  • 26
    Mieda, M. and Sakurai, T. (2011) Bmal1 in the nervous system is essential for normal adaptation of circadian locomotor activity and food intake to periodic feeding. J. Neurosci. 31, 1539115396.
  • 27
    Hughes, M. E., Hong, H. K., Chong, J. L., Indacochea, A. A., Lee, S. S., et al. (2012) Brain-specific rescue of Clock reveals system-driven transcriptional rhythms in peripheral tissue. PLoS Genet. 8, e1002835.
  • 28
    Roybal, K., Theobold, D., Graham, A., DiNieri, J. A., Russo, S. J., et al. (2007) Mania-like behavior induced by disruption of CLOCK. Proc. Natl. Acad. Sci. USA 104, 64066411.
  • 29
    Ozburn, A. R., Larson, E. B., Self, D. W., and McClung, C. A. (2012) Cocaine self-administration behaviors in ClockDelta19 mice. Psychopharmacology (Berl). 223, 169177.
  • 30
    Mukherjee, S., Coque, L., Cao, J. L., Kumar, J., Chakravarty, S., et al. (2010) Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior. Biol. Psychiatry 68, 503511.
  • 31
    Bray, M. S., Shaw, C. A., Moore, M. W., Garcia, R. A., Zanquetta, M. M., et al. (2008) Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. Am. J. Physiol. Heart Circ. Physiol. 294, H1036H1047.
  • 32
    Young, M. E., Razeghi, P., Cedars, A. M., Guthrie, P. H., and Taegtmeyer, H. (2001) Intrinsic diurnal variations in cardiac metabolism and contractile function. Circ. Res. 89, 11991208.
  • 33
    Ko, M. L., Shi, L., Tsai, J. Y., Young, M. E., Neuendorff, N., et al. (2011) Cardiac-specific mutation of Clock alters the quantitative measurements of physical activities without changing behavioral circadian rhythms. J. Biol. Rhythms. 26, 412422.
  • 34
    Durgan, D. J., Tsai, J. Y., Grenett, M. H., Pat, B. M., Ratcliffe, W. F., et al. (2011) Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice. Chronobiol. Int. 28, 187203.
  • 35
    Durgan, D. J. and Young, M. E. (2010) The cardiomyocyte circadian clock: emerging roles in health and disease. Circ. Res. 106, 647658.
  • 36
    Lamia, K. A., Storch, K. F., and Weitz, C. J. (2008) Physiological significance of a peripheral tissue circadian clock. Proc. Natl. Acad. Sci. USA 105, 1517215177.
  • 37
    Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., and Schibler, U. (2007) System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol. 5, e34.
  • 38
    Kornmann, B., Schaad, O., Reinke, H., Saini, C., and Schibler, U. (2007) Regulation of circadian gene expression in liver by systemic signals and hepatocyte oscillators. Cold Spring Harb. Symp. Quant. Biol. 72, 319330.
  • 39
    Le Martelot, G., Claudel, T., Gatfield, D., Schaad, O., Kornmann, B., et al. (2009) REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol. 7, e1000181.
  • 40
    Duez, H., van der Veen, J. N., Duhem, C., Pourcet, B., Touvier, T., et al. (2008) Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha. Gastroenterology 135, 689698.
  • 41
    Noshiro, M., Usui, E., Kawamoto, T., Kubo, H., Fujimoto, K., et al. (2007) Multiple mechanisms regulate circadian expression of the gene for cholesterol 7alpha-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis. J. Biol. Rhythms 22, 299311.
  • 42
    Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., et al. (2000) Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev. 14, 29502961.
  • 43
    Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., et al. (2010) Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature 466, 627631.
  • 44
    Zhang, X., Dube, T. J., and Esser, K. A. (2009) Working around the clock: circadian rhythms and skeletal muscle. J. Appl. Physiol. 107, 16471654.
  • 45
    Feneberg, R. and Lemmer, B. (2004) Circadian rhythm of glucose uptake in cultures of skeletal muscle cells and adipocytes in Wistar-Kyoto, Wistar, Goto-Kakizaki, and spontaneously hypertensive rats. Chronobiol. Int. 21, 521538.
  • 46
    Shimba, S., Ishii, N., Ohta, Y., Ohno, T., Watabe, Y., et al. (2005) Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis. Proc. Natl. Acad. Sci. USA 102, 1207112076.
  • 47
    Guo, B., Chatterjee, S., Li, L., Kim, J. M., Lee, J., et al. (2012) The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway. FASEB J. 26, 34533463.
  • 48
    Shimba, S., Ogawa, T., Hitosugi, S., Ichihashi, Y., Nakadaira, Y., et al. (2011) Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS One 6, e25231.
  • 49
    Kennaway, D. J., Varcoe, T. J., Voultsios, A., and Boden, M. J. (2013) Global loss of bmal1 expression alters adipose tissue hormones, gene expression and glucose metabolism. PLoS One 8, e65255.
  • 50
    Zvonic, S., Ptitsyn, A. A., Conrad, S. A., Scott, L. K., Floyd, Z. E., et al. (2006) Characterization of peripheral circadian clocks in adipose tissues. Diabetes 55, 962970.
  • 51
    Paschos, G. K., Ibrahim, S., Song, W. L., Kunieda, T., Grant, G., et al. (2012) Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat. Med. 18, 17681777.
  • 52
    Bray, M. S. and Young, M. E. (2007) Circadian rhythms in the development of obesity: potential role for the circadian clock within the adipocyte. Obes. Rev. 8, 169181.
  • 53
    Pan, A., Schernhammer, E. S., Sun, Q., and Hu, F. B. (2011) Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in women. Plos Med. 8.
  • 54
    Healy, D. and Waterhouse, J. M. (1995) The circadian system and the therapeutics of the affective-disorders. Pharmacol. Ther. 65, 241263.
  • 55
    Anisimov, V. N. (2003) The role of pineal gland in breast cancer development. Crit. Rev. Oncol. Hematol. 46, 221234.
  • 56
    Schernhammer, E. S. and Thompson, C. A. (2011) Light at night and health: the perils of rotating shift work. Occup. Environ. Med. 68, 310311.
  • 57
    Librodo, P., Buckley, M., Luk, M., and Bisso, A. (2012) Chronotherapeutic drug delivery. J. Infus. Nurs. 35, 329334.