Processing, signaling, and physiological function of chemerin

Authors

  • Andreas Mattern,

    1. Faculty of Biosciences, Pharmacy and Psychology, Institute of Biochemistry, Universität Leipzig, Leipzig, Germany
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    • Both authors contributed equally to this work.

  • Tristan Zellmann,

    1. Faculty of Biosciences, Pharmacy and Psychology, Institute of Biochemistry, Universität Leipzig, Leipzig, Germany
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    • Both authors contributed equally to this work.

  • Annette G. Beck-Sickinger

    Corresponding author
    1. Faculty of Biosciences, Pharmacy and Psychology, Institute of Biochemistry, Universität Leipzig, Leipzig, Germany
    • Address correspondence to: Prof. Dr. Annette G. Beck-Sickinger, Universität Leipzig, Institut für Biochemie, Brüderstraße 34, D-04103 Leipzig, Germany. Tel.: +493419736901; Fax: +493419736909. E-mail: beck-sickinger@uni-leipzig.de

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Abstract

Chemerin is an immunomodulating factor secreted predominantly by adipose tissue and skin. Processed by a variety of proteases linked to inflammation, it activates the G-protein coupled receptor chemokine-like receptor 1 (CMKLR1) and induces chemotaxis in natural killer cells, macrophages, and immature dendritic cells. Recent developments revealed the role of the nonsignaling chemerin receptor C-C chemokine receptor-like 2 (CCRL2) in inflammation. Besides further research establishing its link to inflammatory skin conditions such as psoriasis, functions in healthy skin have also been reported. Here, the current understanding of chemerin processing, signaling and physiological function has been summarized, focusing on the regulation of its activity, its different receptors and its controversially discussed role in diseases. © 2014 IUBMB Life, 66(1):19–26, 2014

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