NAC transcription factor gene regulatory and protein–protein interaction networks in plant stress responses and senescence

Authors

  • Michael K. Jensen,

    1. Department of Biology, University of Copenhagen, Copenhagen, Denmark
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  • Karen Skriver

    Corresponding author
    1. Department of Biology, University of Copenhagen, Copenhagen, Denmark
    • Address correspondence to: Karen Skriver, Department of Biology, University of Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen, Denmark. Tel: +44-20642133; Fax: +45-35321567. E-mail: KSkriver@bio.ku.dk

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Abstract

Plant-specific NAM/ATAF/CUC (NAC) transcription factors (TFs) have recently received considerable attention due to their significant roles in plant development and stress signaling. Here, we summarize progress in understanding NAC TFs in stress responses and senescence. We focus on interactions between the DNA-binding NAC domain and target genes, and between the large, mostly disordered transcription regulatory domain of NAC TFs and protein interaction partners. Recent studies have identified both up-stream regulators of NAC genes and down-stream NAC target genes, outlining regulatory networks associated with NAC–protein interactions. This connects molecular interactions and signal pathway intersections with biological functions with promising use in agriculture. © 2014 IUBMB Life, 66(3):156–166, 2014

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