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REFERENCES

  • 1
    Flegal, K. M.,Carroll, M. D.,Ogden, C. L., and Johnson, C. L. ( 2002) Prevalence and trends in obesity among US adults, 1999–2000. JAMA 288, 17231727.
  • 2
    Amos, A. F.,McCarty, D. J., and Zimmet, P. ( 1997) The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabet. Med. 14 ( Suppl. 5), S1S85.
  • 3
    DeFronzo, R. A.,Jacot, E.,Jequier, E.,Maeder, E.,Wahren, J., and Felber, J. P. ( 1981) The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30, 10001007.
  • 4
    Dagenais, G. R.,Tancredi, R. G., and Zierler, K. L. ( 1976) Free fatty acid oxidation by forearm muscle at rest, and evidence for an intramuscular lipid pool in the human forearm. J. Clin. Invest. 58, 421431.
  • 5
    Kelley, D. E.,Mokan, M.,Simoneau, J. A., and Mandarino, L. J. ( 1993) Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J. Clin. Invest. 92, 9198.
  • 6
    Belfort, R.,Mandarino, L.,Kashyap, S.,Wirfel, K.,Pratipanawatr, T.,Berria, R.,Defronzo, R. A., and Cusi, K. ( 2005) Dose-response effect of elevated plasma free fatty acid on insulin signaling. Diabetes 54, 16401648.
  • 7
    Oakes, N. D.,Cooney, G. J.,Camilleri, S.,Chisholm, D. J., and Kraegen, E. W. ( 1997) Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 46, 17681774.
  • 8
    Boden, G.,Chen, X.,Ruiz, J.,White, J. V., and Rossetti, L. ( 1994) Mechanisms of fatty acid-induced inhibition of glucose uptake. J. Clin. Invest. 93, 24382446.
  • 9
    Itani, S. I.,Ruderman, N. B.,Schmieder, F., and Boden, G. ( 2002) Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 51, 20052011.
  • 10
    Campbell, J.,Martucci, A. D., and Green, G. R. ( 1964) Plasma albumin as an acceptor of free fatty acids. Biochem. J. 93, 183189.
  • 11
    Abumrad, N.,Harmon, C., and Ibrahimi, A. ( 1998) Membrane transport of long-chain fatty acids: evidence for a facilitated process. J. Lipid. Res. 39, 23092318.
  • 12
    Hamilton, J. A. ( 1998) Fatty acid transport: difficult or easy? J. Lipid. Res. 39, 467481.
  • 13
    Bonen, A.,Luiken, J. J.,Arumugam, Y.,Glatz, J. F., and Tandon, N. N. ( 2000) Acute regulation of fatty acid uptake involves the cellular redistribution of fatty acid translocase. J. Biol. Chem. 275, 1450114508.
  • 14
    Chabowski, A.,Coort, S. L.,Calles-Escandon, J.,Tandon, N. N.,Glatz, J. F.,Luiken, J. J., and Bonen, A. ( 2004) Insulin stimulates fatty acid transport by regulating expression of FAT/CD36 but not FABPpm. Am. J. Physiol. Endocrinol. Metab. 287, E781E789.
  • 15
    Coburn, C. T.,Knapp, F. F.Jr.,Febbraio, M.,Beets, A. L.,Silverstein, R. L., and Abumrad, N. A. ( 2000) Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice. J. Biol. Chem. 275, 3252332529.
  • 16
    Schwieterman, W.,Sorrentino, D.,Potter, B. J.,Rand, J.,Kiang, C. L.,Stump, D., and Berk, P. D. ( 1988) Uptake of oleate by isolated rat adipocytes is mediated by a 40-kDa plasma membrane fatty acid binding protein closely related to that in liver and gut. Proc. Natl. Acad. Sci. USA 85, 359363.
  • 17
    Gimeno, R. E.,Ortegon, A. M.,Patel, S.,Punreddy, S.,Ge, P.,Sun, Y.,Lodish, H. F., and Stahl, A. ( 2003) Characterization of a heart-specific fatty acid transport protein. J. Biol. Chem. 278, 1603916044.
  • 18
    Schaffer, J. E., and Lodish, H. F. ( 1994) Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell 79, 427436.
  • 19
    Hirsch, D.,Stahl, A., and Lodish, H. F. ( 1998) A family of fatty acid transporters conserved from mycobacterium to man. Proc. Natl. Acad. Sci. USA 95, 86258629.
  • 20
    Febbraio, M.,Hajjar, D. P., and Silverstein, R. L. ( 2001) CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism. J. Clin. Invest. 108, 785791.
  • 21
    Febbraio, M.,Abumrad, N. A.,Hajjar, D. P.,Sharma, K.,Cheng, W.,Pearce, S. F., and Silverstein, R. L. ( 1999) A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J. Biol. Chem. 274, 1905519062.
  • 22
    Luiken, J. J.,Koonen, D. P.,Willems, J.,Zorzano, A.,Becker, C.,Fischer, Y.,Tandon, N. N.,Van Der Vusse, G. J.,Bonen, A., and Glatz, J. F. ( 2002) Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36. Diabetes 51, 31133119.
  • 23
    Luiken, J. J.,Coort, S. L.,Willems, J.,Coumans, W. A.,Bonen, A.,van der Vusse, G. J., and Glatz, J. F. ( 2003) Contraction-induced fatty acid translocase/CD36 translocation in rat cardiac myocytes is mediated through AMP-activated protein kinase signaling. Diabetes 52, 16271634.
  • 24
    Clarke, D. C.,Miskovic, D.,Han, X. X.,Calles-Escandon, J.,Glatz, J. F.,Luiken, J. J.,Heikkila, J. J., and Bonen, A. ( 2004) Overexpression of membrane-associated fatty acid binding protein (FABPpm) in vivo increases fatty acid sarcolemmal transport and metabolism. Physiol. Genomics 17, 3137.
  • 25
    Wu, Q.,Ortegon, A. M.,Tsang, B.,Doege, H.,Feingold, K. R., and Stahl, A. ( 2006) FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity. Mol. Cell. Biol. 26, 34553467.
  • 26
    Nickerson, J., and Bonen, A. ( 2005) Defining a role for skeletal muscle fatty acid transport proteins. In 2nd Northern Lights Conference. Canadian Federation of Biological Societies. p. F47, Guelph, Ontario, Canada.
  • 27
    Jeukendrup, A. E. ( 2002) Regulation of fat metabolism in skeletal muscle. Ann. NY Acad. Sci. 967, 217235.
  • 28
    Kiens, B. ( 2006) Skeletal muscle lipid metabolism in exercise and insulin resistance. Physiol. Rev. 86, 205243.
  • 29
    Bruce, C. R.,Brolin, C.,Turner, N.,Cleasby, M. E.,van der Leij, F. R.,Cooney, G. J., and Kraegen, E. W. ( 2007) Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification. Am. J. Physiol. Endocrinol. Metab. 292, E1231E1237.
  • 30
    Kiens, B. ( 1997) Effect of endurance training on fatty acid metabolism: local adaptations. Med. Sci. Sports Exerc. 29, 640645.
  • 31
    Turcotte, L. P.,Srivastava, A. K., and Chiasson, J. L. ( 1997) Fasting increases plasma membrane fatty acid-binding protein (FABP(PM)) in red skeletal muscle. Mol. Cell. Biochem. 166, 153158.
  • 32
    Roepstorff, C.,Helge, J. W.,Vistisen, B., and Kiens, B. ( 2004) Studies of plasma membrane fatty acid-binding protein and other lipid-binding proteins in human skeletal muscle. Proc. Nutr. Soc. 63, 239244.
  • 33
    Bruce, C. R.,Anderson, M. J.,Carey, A. L.,Newman, D. G.,Bonen, A.,Kriketos, A. D.,Cooney, G. J., and Hawley, J. A. ( 2003) Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status. J. Clin. Endocrinol. Metab. 88, 54445451.
  • 34
    Simoneau, J. A.,Veerkamp, J. H.,Turcotte, L. P., and Kelley, D. E. ( 1999) Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss. FASEB J. 13, 20512060.
  • 35
    Bonen, A.,Parolin, M. L.,Steinberg, G. R.,Calles-Escandon, J.,Tandon, N. N.,Glatz, J. F.,Luiken, J. J.,Heigenhauser, G. J., and Dyck, D. J. ( 2004) Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36. FASEB J. 18, 11441146.
  • 36
    Kim, J. Y.,Hickner, R. C.,Cortright, R. L.,Dohm, G. L., and Houmard, J. A. ( 2000) Lipid oxidation is reduced in obese human skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 279, E1039E1044.
  • 37
    Simoneau, J. A., and Kelley, D. E. ( 1997) Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM. J. Appl. Physiol. 83, 166171.
  • 38
    Perdomo, G.,Commerford, S. R.,Richard, A. M.,Adams, S. H.,Corkey, B. E.,O'Doherty, R. M., and Brown, N. F. ( 2004) Increased beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite intramyocellular lipid accumulation. J. Biol. Chem. 279, 2717727186.
  • 39
    Ritov, V. B.,Menshikova, E. V.,He, J.,Ferrell, R. E.,Goodpaster, B. H., and Kelley, D. E. ( 2005) Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes 54, 814.
  • 40
    Koves, T. R.,Ussher, J. R.,Noland, R. C.,Slentz, D.,Mosedale, M.,Ilkayeva, O.,Bain, J.,Stevens, R.,Dyck, J. R.,Newgard, C. B.,Lopaschuk, G. D., and Muoio, D. M. ( 2008) Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 7, 4556.
  • 41
    Kelley, D. E.,He, J.,Menshikova, E. V., and Ritov, V. B. ( 2002) Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51, 29442950.
  • 42
    Marra, M.,Scalfi, L.,Covino, A.,Esposito-Del Puente, A., and Contaldo, F. ( 1998) Fasting respiratory quotient as a predictor of weight changes in non-obese women. Int. J. Obes. Relat. Metab. Disord. 22, 601603.
  • 43
    Zurlo, F.,Lillioja, S.,Esposito-Del Puente, A.,Nyomba, B. L.,Raz, I.,Saad, M. F.,Swinburn, B. A.,Knowler, W. C.,Bogardus, C., and Ravussin, E. ( 1990) Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. Am. J. Physiol. 259, E650E657.
  • 44
    Kelley, D. E.,Goodpaster, B.,Wing, R. R., and Simoneau, J. A. ( 1999) Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am. J. Physiol. 277, E1130E1141.
  • 45
    Hulver, M. W.,Berggren, J. R.,Cortright, R. N.,Dudek, R. W.,Thompson, R. P.,Pories, W. J.,MacDonald, K. G.,Cline, G. W.,Shulman, G. I.,Dohm, G. L., and Houmard, J. A. ( 2003) Skeletal muscle lipid metabolism with obesity. Am. J. Physiol. Endocrinol. Metab. 284, E741E747.
  • 46
    Essen, B.,Jansson, E.,Henriksson, J.,Taylor, A. W., and Saltin, B. ( 1975) Metabolic characteristics of fibre types in human skeletal muscle. Acta Physiol. Scand. 95, 153165.
  • 47
    Hickey, M. S.,Carey, J. O.,Azevedo, J. L.,Houmard, J. A.,Pories, W. J.,Israel, R. G., and Dohm, G. L. ( 1995) Skeletal muscle fiber composition is related to adiposity and in vitro glucose transport rate in humans. Am. J. Physiol. 268, E453E457.
  • 48
    Tanner, C. J.,Barakat, H. A.,Dohm, G. L.,Pories, W. J.,MacDonald, K. G.,Cunningham, P. R.,Swanson, M. S., and Houmard, J. A. ( 2002) Muscle fiber type is associated with obesity and weight loss. Am. J. Physiol. Endocrinol. Metab. 282, E1191E1196.
  • 49
    Gray, R. E.,Tanner, C. J.,Pories, W. J.,MacDonald, K. G., and Houmard, J. A. ( 2003) Effect of weight loss on muscle lipid content in morbidly obese subjects. Am. J. Physiol. Endocrinol. Metab. 284, E726E732.
  • 50
    Berggren, J. R.,Boyle, K. E.,Chapman, W. H., and Houmard, J. A. ( 2008) Skeletal muscle lipid oxidation and obesity: influence of weight loss and exercise. Am. J. Physiol. Endocrinol. Metab. 294, E726E732.
  • 51
    Berggren, J. R.,Tanner, C. J., and Houmard, J. A. ( 2007) Primary cell cultures in the study of human muscle metabolism. Exerc. Sport Sci. Rev. 35, 5661.
  • 52
    Hulver, M. W.,Berggren, J. R.,Carper, M. J.,Miyazaki, M.,Ntambi, J. M.,Hoffman, E. P.,Thyfault, J. P.,Stevens, R.,Dohm, G. L.,Houmard, J. A., and Muoio, D. M. ( 2005) Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metab. 2, 251261.
  • 53
    Guesbeck, N. R.,Hickey, M. S.,MacDonald, K. G.,Pories, W. J.,Harper, I.,Ravussin, E.,Dohm, G. L., and Houmard, J. A. ( 2001) Substrate utilization during exercise in formerly morbidly obese women. J. Appl. Physiol. 90, 10071012.
  • 54
    Thyfault, J. P.,Kraus, R. M.,Hickner, R. C.,Howell, A. W.,Wolfe, R. R., and Dohm, G. L. ( 2004) Impaired plasma fatty acid oxidation in extremely obese women. Am. J. Physiol. Endocrinol. Metab. 287, E10761081.
  • 55
    Krssak, M.,Falk Petersen, K.,Dresner, A.,DiPietro, L.,Vogel, S. M.,Rothman, D. L.,Roden, M., and Shulman, G. I. ( 1999) Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 42, 113116.
  • 56
    Dobbins, R. L.,Szczepaniak, L. S.,Bentley, B.,Esser, V.,Myhill, J., and McGarry, J. D. ( 2001) Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats. Diabetes 50, 123130.
  • 57
    Jacob, S.,Machann, J.,Rett, K.,Brechtel, K.,Volk, A.,Renn, W.,Maerker, E.,Matthaei, S.,Schick, F.,Claussen, C. D., and Haring, H. U. ( 1999) Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 48, 11131119.
  • 58
    Jazet, I. M.,Schaart, G.,Gastaldelli, A.,Ferrannini, E.,Hesselink, M. K.,Schrauwen, P.,Romijn, J. A.,Maassen, J. A.,Pijl, H.,Ouwens, D. M., and Meinders, A. E. ( 2008) Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients. Diabetologia 51, 309319.
  • 59
    Lara-Castro, C.,Newcomer, B. R.,Rowell, J.,Wallace, P.,Shaughnessy, S. M.,Munoz, A. J.,Shiflett, A. M.,Rigsby, D. Y.,Lawrence, J. C.,Bohning, D. E.,Buchthal, S., and Garvey, W. T. ( 2008) Effects of short-term very low-calorie diet on intramyocellular lipid and insulin sensitivity in nondiabetic and type 2 diabetic subjects. Metabolism 57, 18.
  • 60
    Greco, A. V.,Mingrone, G.,Giancaterini, A.,Manco, M.,Morroni, M.,Cinti, S.,Granzotto, M.,Vettor, R.,Camastra, S., and Ferrannini, E. ( 2002) Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion. Diabetes 51, 144151.
  • 61
    Goodpaster, B. H.,He, J.,Watkins, S., and Kelley, D. E. ( 2001) Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J. Clin. Endocrinol. Metab. 86, 57555761.
  • 62
    Schenk, S., and Horowitz, J. F. ( 2007) Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance. J. Clin. Invest. 117, 16901698.
  • 63
    Bell, R. M., and Coleman, R. A. ( 1980) Enzymes of glycerolipid synthesis in eukaryotes. Annu. Rev. Biochem. 49, 459487.
  • 64
    Lehner, R. and Kuksis, A. ( 1996) Biosynthesis of triacylglycerols. Prog. Lipid. Res. 35, 169201.
  • 65
    Bagnato, C., and Igal, R. A. ( 2003) Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts. J. Biol. Chem. 278, 5220352211.
  • 66
    Liu, L.,Zhang, Y.,Chen, N.,Shi, X.,Tsang, B., and Yu, Y. H. ( 2007) Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. J. Clin. Invest. 117, 16791689.
  • 67
    Pinnamaneni, S. K.,Southgate, R. J.,Febbraio, M. A., and Watt, M. J. ( 2006) Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro. Diabetologia 49, 30273037.
  • 68
    Listenberger, L. L.,Han, X.,Lewis, S. E.,Cases, S.,Farese, R. V.Jr.,Ory, D. S., and Schaffer, J. E. ( 2003) Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc. Natl. Acad. Sci. USA 100, 30773082.
  • 69
    Folli, F.,Saad, M. J.,Backer, J. M., and Kahn, C. R. ( 1992) Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat. J. Biol. Chem. 267, 2217122177.
  • 70
    Chang, L.,Chiang, S. H., and Saltiel, A. R. ( 2004) Insulin signaling and the regulation of glucose transport. Mol. Med. 10, 6571.
  • 71
    Frosig, C.,Rose, A. J.,Treebak, J. T.,Kiens, B.,Richter, E. A., and Wojtaszewski, J. F. ( 2007) Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160. Diabetes 56, 20932102.
  • 72
    Kramer, H. F.,Witczak, C. A.,Taylor, E. B.,Fujii, N.,Hirshman, M. F., and Goodyear, L. J. ( 2006) AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle. J. Biol. Chem. 281, 3147831485.
  • 73
    Itani, S. I.,Zhou, Q.,Pories, W. J.,MacDonald, K. G., and Dohm, G. L. ( 2000) Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity. Diabetes 49, 13531358.
  • 74
    Newton, A. C. ( 1995) Protein kinase C: structure, function, and regulation. J. Biol. Chem. 270, 2849528498.
  • 75
    Cortright, R. N.,Azevedo, J. L.Jr.,Zhou, Q.,Sinha, M.,Pories, W. J.,Itani, S. I., and Dohm, G. L. ( 2000) Protein kinase C modulates insulin action in human skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 278, E553E562.
  • 76
    Schmitz-Peiffer, C. ( 2002) Protein kinase C and lipid-induced insulin resistance in skeletal muscle. Ann. NY Acad. Sci. 967, 146157.
  • 77
    Ellis, B. A.,Poynten, A.,Lowy, A. J.,Furler, S. M.,Chisholm, D. J.,Kraegen, E. W., and Cooney, G. J. ( 2000) Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle. Am. J. Physiol. Endocrinol. Metab. 279, E554E560.
  • 78
    Dohm, G. L.,Tapscott, E. B.,Pories, W. J.,Dabbs, D. J.,Flickinger, E. G.,Meelheim, D.,Fushiki, T.,Atkinson, S. M.,Elton, C. W., and Caro, J. F. ( 1988) An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects. J. Clin. Invest. 82, 486494.
  • 79
    Chalkley, S. M.,Hettiarachchi, M.,Chisholm, D. J., and Kraegen, E. W. ( 1998) Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat. Metabolism 47, 11211126.
  • 80
    Bajaj, M.,Suraamornkul, S.,Romanelli, A.,Cline, G. W.,Mandarino, L. J.,Shulman, G. I., and DeFronzo, R. A. ( 2005) Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients. Diabetes 54, 31483153.
  • 81
    Yu, C.,Chen, Y.,Cline, G. W.,Zhang, D.,Zong, H.,Wang, Y.,Bergeron, R.,Kim, J. K.,Cushman, S. W.,Cooney, G. J.,Atcheson, B.,White, M. F.,Kraegen, E. W., and Shulman, G. I. ( 2002) Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem. 277, 5023050236.
  • 82
    Hannun, Y. A., and Obeid, L. M. ( 2002) The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J. Biol. Chem. 277, 2584725850.
  • 83
    Merrill, A. H.Jr., and Jones, D. D. ( 1990) An update of the enzymology and regulation of sphingomyelin metabolism. Biochim. Biophys. Acta 1044, 112.
  • 84
    Adams, J. M.II,Pratipanawatr, T.,Berria, R.,Wang, E.,DeFronzo, R. A.,Sullards, M. C., and Mandarino, L. J. ( 2004) Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. Diabetes 53, 2531.
  • 85
    Turinsky, J.,O'Sullivan, D. M., and Bayly, B. P. ( 1990) 1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo. J. Biol. Chem. 265, 1688016885.
  • 86
    Straczkowski, M.,Kowalska, I.,Nikolajuk, A.,Dzienis-Straczkowska, S.,Kinalska, I.,Baranowski, M.,Zendzian-Piotrowska, M.,Brzezinska, Z., and Gorski, J. ( 2004) Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle. Diabetes 53, 12151221.
  • 87
    Straczkowski, M.,Kowalska, I.,Baranowski, M.,Nikolajuk, A.,Otziomek, E.,Zabielski, P.,Adamska, A.,Blachnio, A.,Gorski, J., and Gorska, M. ( 2007) Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes. Diabetologia 50, 23662373.
  • 88
    Serlie, M. J.,Meijer, A. J.,Groener, J. E.,Duran, M.,Endert, E.,Fliers, E.,Aerts, J. M., and Sauerwein, H. P. ( 2007) Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects. J. Clin. Endocrinol. Metab. 92, 15241529.
  • 89
    Holland, W. L.,Brozinick, J. T.,Wang, L. P.,Hawkins, E. D.,Sargent, K. M.,Liu, Y.,Narra, K.,Hoehn, K. L.,Knotts, T. A.,Siesky, A.,Nelson, D. H.,Karathanasis, S. K.,Fontenot, G. K.,Birnbaum, M. J., and Summers, S. A. ( 2007) Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 5, 167179.
  • 90
    Hajduch, E.,Balendran, A.,Batty, I. H.,Litherland, G. J.,Blair, A. S.,Downes, C. P., and Hundal, H. S. ( 2001) Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. Diabetologia 44, 173183.
  • 91
    Chavez, J. A., and Summers, S. A. ( 2003) Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. Arch. Biochem. Biophys. 419, 101109.
  • 92
    Skovbro, M.,Baranowski, M.,Skov-Jensen, C.,Flint, A.,Dela, F.,Gorski, J., and Helge, J. W. ( 2008) Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity. Diabetologia 51, 12531260.
  • 93
    Cusi, K.,Maezono, K.,Osman, A.,Pendergrass, M.,Patti, M. E.,Pratipanawatr, T.,DeFronzo, R. A.,Kahn, C. R., and Mandarino, L. J. ( 2000) Insulin resistance differentially affects the PI3-kinase- and MAP kinase-mediated signaling in human muscle. J. Clin. Invest. 105, 311320.
  • 94
    Timmers, S.,Schrauwen, P., and de Vogel, J. ( 2008) Muscular diacylglycerol metabolism and insulin resistance. Physiol. Behav. 94, 242251.
  • 95
    Turinsky, J.,Bayly, B. P., and O'Sullivan, D. M. ( 1991) 1,2-Diacylglycerol and ceramide levels in rat liver and skeletal muscle in vivo. Am. J. Physiol. 261, E620E627.
  • 96
    Itani, S. I.,Pories, W. J.,Macdonald, K. G., and Dohm, G. L. ( 2001) Increased protein kinase C theta in skeletal muscle of diabetic patients. Metabolism 50, 553557.
  • 97
    Sebastian, D.,Herrero, L.,Serra, D.,Asins, G., and Hegardt, F. G. ( 2007) CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance. Am. J. Physiol. Endocrinol. Metab. 292, E677E686.
  • 98
    Bruce, C. R.,Thrush, A. B.,Mertz, V. A.,Bezaire, V.,Chabowski, A.,Heigenhauser, G. J., and Dyck, D. J. ( 2006) Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content. Am. J. Physiol. Endocrinol. Metab. 291, E99E107.
  • 99
    Dube, J. J.,Amati, F.,Stefanovic-Racic, M.,Toledo, F. G.,Sauers, S. E., and Goodpaster, B. H. ( 2008) Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited. Am. J. Physiol. Endocrinol. Metab. 294, E882E888.