Adipose tissue: A motor for the inflammation associated with obesity

Authors

  • Vidula Vachharajani,

    1. Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA
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  • D. Neil Granger

    Corresponding author
    1. Department of Molecular & Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    • Department of Molecular & Cellular Physiology, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, Louisiana 71130-3932, USA
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    • Tel: +(318) 675-6011. Fax: +(318) 675-6005


Abstract

Obesity is a worldwide epidemic that continues to grow at an alarming rate. This condition increases the morbidity and mortality associated with both acute and chronic diseases. Some of the deleterious consequences of obesity have been attributed to its induction of a low-grade chronic inflammatory state that arises from the production and secretion of inflammatory mediators from the expanded pool of activated adipocytes. This review focuses on the mechanisms that underlie the proposed link between obesity and inflammation, and it addresses how obesity-induced inflammation may account for increased morbidity and mortality that is associated with a diverse group of diseases. © 2009 IUBMB IUBMB Life, 61(4): 424–430, 2009

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