Regulation and roles for claudin-family tight junction proteins

Authors

  • Mary K. Findley,

    1. Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia
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  • Michael Koval

    Corresponding author
    1. Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia
    2. Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia
    • Division of Pulmonary, Allergy, and Critical Care Medicine, Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael St., Suite 205, Atlanta, GA 30322
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    • Tel: +404-712-2976. Fax:+404-712-2974


Abstract

Transmembrane proteins known as claudins play a critical role in tight junctions by regulating paracellular barrier permeability. The control of claudin assembly into tight junctions requires a complex interplay between several classes of claudins, other transmembrane proteins and scaffold proteins. Claudins are also subject to regulation by post-translational modifications including phosphorylation and palmitoylation. Several human diseases have been linked to claudin mutations, underscoring the physiologic function of these proteins. Roles for claudins in regulating cell phenotype and growth control also are beginning to emerge, suggesting a multifaceted role for claudins in regulation of cells beyond serving as a simple structural element of tight junctions. © 2009 IUBMB IUBMB Life, 61(4):431–437, 2009

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