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GABA increases Ca2+ in cerebellar granule cell precursors via depolarization: Implications for proliferation
Article first published online: 23 APR 2009
Copyright © 2009 International Union of Biochemistry and Molecular Biology, Inc.
Volume 61, Issue 5, pages 496–503, May 2009
How to Cite
Dave, K. A. and Bordey, A. (2009), GABA increases Ca2+ in cerebellar granule cell precursors via depolarization: Implications for proliferation. IUBMB Life, 61: 496–503. doi: 10.1002/iub.185
- Issue published online: 23 APR 2009
- Article first published online: 23 APR 2009
- Manuscript Accepted: 21 DEC 2008
- Manuscript Received: 25 SEP 2008
- National Institute of Health. Grant Numbers: NS048256, DC007681
- National Science Foundation Graduate Research Fellowship
- GABA receptor;
- external granule cell layer;
The amino acids glutamate and gamma-aminobutyric acid (GABA) have primarily been characterized as the most prevalent excitatory and inhibitory, respectively, neurotransmitters in the vertebrate central nervous system. However, the role of these signaling molecules extends far beyond the synapse. GABA, glutamate, and their complement of receptors are essential signaling molecules that regulate developmental processes in both embryonic and young adult mammals. In this review, we describe the current knowledge on the role of GABA and glutamate in development, focusing on the perinatal cerebellum. We will then present novel data suggesting that GABA depolarizes granule cell precursors via GABAA receptors, which leads to calcium increases in these cells. Finally, we will consider the role of GABA and glutamate signaling on cell proliferation and perhaps neural cancers. From our review of the literature and these data, we hypothesize that GABAA receptors and metabotropic glutamate receptors may be a novel target for the pharmacological regulation of the cerebellar tumors, medulloblastomas. © 2009 IUBMB IUBMB Life, 61(5): 496–503, 2009