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Evolutionary significance of self-acylation property in acyl carrier proteins
Article first published online: 20 JUL 2009
DOI: 10.1002/iub.224
Copyright © 2009 Wiley Periodicals, Inc.
Additional Information
How to Cite
Misra, A., Surolia, N. and Surolia, A. (2009), Evolutionary significance of self-acylation property in acyl carrier proteins. IUBMB Life, 61: 853–859. doi: 10.1002/iub.224
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Tel: 91-11-26717102. Fax: 91-11-26717104.
Publication History
- Issue published online: 20 JUL 2009
- Article first published online: 20 JUL 2009
- Manuscript Accepted: 6 APR 2009
- Manuscript Received: 13 DEC 2008
Funded by
- Centre of excellence grant from the Department of Biotechnology (DBT)
- Government of India
- Department of Science and Technology
- Council of Scientific and Industrial Research
- Abstract
- Article
- References
- Cited By
Keywords:
- acyl carrier protein;
- self-acylation;
- fatty acid synthesis;
- malonyl-CoA;
- Escherichia coli
Abstract
Acyl carrier protein is an integral component of many cellular metabolic processes. A number of studies have reported self-acylation behavior in acyl carrier proteins. Although ACPs exhibit high levels of similarity in their primary and tertiary structures, self-acylation behavior is restricted to only some ACPs that can be classified into two major families based on their function. The first family of ACPs is involved in polyketide biosynthesis, whereas the second family participates in fatty acid synthesis. Facilitated by the growing number of genome sequences available for analyses, large-scale phylogenetic studies were used in these studies to uncover as to how self-acylation behavior of acyl carrier proteins is linked with the evolution of metabolic pathways in organisms. These studies show that self-acylation behavior in acyl carrier proteins was lost during the course of evolution, with certain organisms and organelles viz. plastids, retaining it for specified functions. © 2009 IUBMB IUBMB Life, 61(8): 853–859, 2009