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Mitochondrial ATP-independent chaperones

  1. Nikos Petrakis1,2,
  2. Felicity Alcock1,†,
  3. Kostas Tokatlidis1,3,*

Article first published online: 7 JUL 2009

DOI: 10.1002/iub.235

Issue

IUBMB Life

IUBMB Life

Volume 61, Issue 9, pages 909–914, September 2009

Additional Information

How to Cite

Petrakis, N., Alcock, F. and Tokatlidis, K. (2009), Mitochondrial ATP-independent chaperones. IUBMB Life, 61: 909–914. doi: 10.1002/iub.235

Author Information

  1. 1

    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas (IMBB-FORTH), Heraklion, Crete, Greece

  2. 2

    Department of Chemistry, University of Crete, Heraklion, Crete, Greece

  3. 3

    Department of Materials Science and Technology, University of Crete, Heraklion, Crete, Greece

  1. †

    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia

*Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas (IMBB-FORTH), Nikolaou Plastira 100, Heraklion 70013, Crete, Greece

Publication History

  1. Issue published online: 21 AUG 2009
  2. Article first published online: 7 JUL 2009
  3. Manuscript Accepted: 17 MAY 2009
  4. Manuscript Received: 9 APR 2009

Funded by

  • GSRT
  • BBSRC
  • IMBB-FORTH
  • University of Crete and the European Social Fund

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Keywords:

  • mitochondria;
  • chaperones;
  • yeast;
  • ATP;
  • small Tims;
  • membranes

Abstract

Mitochondria possess a dedicated-chaperone system in the intermembrane space, the small Tims that are ubiquitous in all eukaryotes from yeast to man. They escort membrane proteins to the outer or the inner membrane for proper insertion. These mitochondrial chaperones do not require external energy to perform their function and have structural similarities to other ATP-independent chaperones. Here, we discuss their structural properties and how these relate to their chaperoning function in the mitochondrial intermembrane space. © 2009 IUBMB IUBMB Life 61(9): 909–914, 2009

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