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Micro-RNA-375 inhibits lung surfactant secretion by altering cytoskeleton reorganization
Article first published online: 14 DEC 2009
DOI: 10.1002/iub.286
Copyright © 2009 International Union of Biochemistry and Molecular Biology, Inc.
Additional Information
How to Cite
Zhang, H., Mishra, A., Chintagari, N. R., Gou, D. and Liu, L. (2010), Micro-RNA-375 inhibits lung surfactant secretion by altering cytoskeleton reorganization. IUBMB Life, 62: 78–83. doi: 10.1002/iub.286
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Publication History
- Issue published online: 18 DEC 2009
- Article first published online: 14 DEC 2009
- Manuscript Accepted: 9 NOV 2009
- Manuscript Received: 21 OCT 2009
Funded by
- NIH. Grant Numbers: R01 HL-083188, R01 HL-052146, R01 HL-071628
- Abstract
- Article
- References
- Cited By
Keywords:
- miR-375;
- lung surfactant secretion;
- cytoskeleton;
- type II cells
Abstract
Lung surfactant is secreted via exocytosis of lamellar bodies from alveolar epithelial type II cells. Whether micro-RNAs regulate lung surfactant secretion is unknown. Micro-RNA-375 (miR-375) has been shown to be involved in insulin secretion. In this article, we report that the overexpression of miR-375 inhibited lung surfactant secretion. However, miR-125a, miR-30a, miR-1, miR-382 and miR-101 did not influence lung surfactant secretion. miR-375 had no effects on surfactant synthesis or the formation of lamellar bodies. However, miR-375 did abolish the lung surfactant secretagogue-induced disassembly and reassembly of cytoskeleton. Our results suggest that miR-375 regulates surfactant secretion via the reorganization of cytoskeleton. © 2009 IUBMB IUBMB Life, 62(1):78–83, 2010